Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2019 Pilot

Inclusion Criteria: This study included patients with B-cell precursor ALL (BCP-ALL) diagnosed or confirmed in one of the clinics participating in the study. Also following criteria should be considered at the diagnosis for each case: 1. Age at diagnosis at 1 to 18 years. 2. The start of induction therapy within a time interval of study recruitment phase. 3. The diagnosis of BCP-ALL is to be proved by the morphological, cytochemical, and immunological analysis of tumor cells in bone marrow in the reference laboratories of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology (D. Rogachev NMRCPHOI). 4. CD19 expression on tumor cells. 5. Informed consent of the patient parents (guardians) Exclusion Criteria: 1. Any non-compliance with the inclusion criteria. 2. ALL is a second malignancy. 3. There is severe concomitant disease, which significantly impedes chemotherapy protocol (such as multiple malformations, heart diseases, metabolic disorders, etc.); 4. The patient was treated before for a long time with cytotoxic drugs. 5. Initial CNS (central nervous system) involvement (status CNSII or CNSIII). 6. Initial leukocyte count ≥100×109/L (except for patients with significant translocations). 7. Patients not achieved cytological remission after induction