Disability Following Hospitalization in People of Working-age Surviving SARS-CoV-2 Infection - COVID-19

Assistance Publique - Hôpitaux de Paris530 enrolled

Overview

The purpose of the study is to describe disability following hospitalization in people of working-age surviving COVID-19.

In December 2019, the Wuhan Municipal Health Committee in China identified an outbreak with viral pneumonia cases of unknown cause. Coronavirus RNA was identified as the causal agent. The disease caused by SARS-CoV-2 has been named COVID-19. While most people with COVID-19 develop uncomplicated illness, approximately 14% develop severe forms of the disease and 5% are critically ill, potentially leaving survivors with non-fatal sequelae. To date, the long-term burden of COVID-19 and patients' perspectives and needs have been left unaddressed. As compared to 2003 SARS outbreak, one can anticipate persisting disability in COVID-19 survivors, including specific post-COVID and non-specific post-intensive care syndromes. The investigators hypothesize that dramatic COVID-19-specific and non-specific mid- and long-term disabilities would persist in people surviving COVID-19. The main objective will be to provide a deep understanding of non-fatal health outcomes in people surviving COVID-19, by comprehensively and systematically mapping and monitoring, within the WHO ICF framework, disability levels and profiles, in the mid and long terms in people surviving COVID-19. Disability levels will be assessed at 12 (±7) and 36 (±3) months using: * Parts 1a (impairments of body functions) and 2 (activity limitation and participation restriction) of the WHO ICF checklist v2.1, administered by a health care provider, and * Self-administered 36-item WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) A. The secondary objectives will be to describe COVID-19 specific and non-specific impairments, activity limitations and participation restriction at 12 (±7) and 36 (±3) months in people surviving COVID-19: * Impairments, participation restrictions and health-related quality of life (HRQoL) at 12 (±7) and 36 (±3) months will be assessed using online specific self-administered questionnaires and face-to-face specific tests. * Non-pharmacological / pharmacological treatments at baseline, 12 (±7) and 36 (±3) months will be self-reported. * Total costs, cost drivers and estimated Years-Lived with Disability (YLDs) at 12 (±7) and (36 (±3) months will be calculated. B. Another secondary objective will be to assess the burden of the patient's SARS-CoV-2 infection on the patient's close relative, between M12-inclusion and M36 patient visits. • The burden on patient's close relative will be assessed using specific printed self-administered questionnaires.

Study Type

OBSERVATIONAL

Enrollment

530

Conditions

COVID-19

Interventions

HospitalizationOTHER

Hospitalization in intensive care and non-intensive care units for COVID-19 followed by usual care

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults of working-age (18 to 70 years), * Hospitalization during the prespecified inclusion period (from March 2020 to March 2021) (NB : in case of transferred patients, inclusion in the DisCOVID study must be carried out in the first place of admission for COVID), * Laboratory-confirmed SARS-CoV-2 and/or CT-scan showing typical radiological findings, * SARS-CoV-2 of any duration, * Ability to comply with study visits, * Informed written consent Exclusion Criteria: * Return home in less than 72 hours * Absence of health insurance, * Inability to fluently speak and/or read French language, * People under tutorship or curatorship and protected adults.

Locations (1)

Cochin Hospital

Paris, France

Outcomes

Primary Outcomes

Post-acute COVID-19 disability from the care provider's perspective, 12 months after hospitalization

Disability levels will be assessed using Part 1a (impairments of body functions) and 2 (activity limitation and participation restriction) of the WHO ICF checklist v2.1, administered by a health care provider.

Time frame: At 12 (±7) months after hospitalization

Post-acute COVID-19 disability from the care provider's perspective, 36 months after hospitalization

Time frame: 36 (±3) months after hospitalization

Post-acute COVID-19 disability from the patient's perspectives, 12 months after hospitalization

Disability levels will be assessed using the self-administered 36-item WHO Disability Assessment Schedule 2.0 (WHODAS 2.0)

Time frame: At 12 (±7) months after hospitalization

Post-acute COVID-19 disability from the patient's perspectives, 36 months after hospitalization

Disability levels will be assessed using the self-administered 36-item WHO Disability Assessment Schedule 2.0 (WHODAS 2.0)

Time frame: 36 (±3) months after hospitalization

Secondary Outcomes

Type of treatments

Non-pharmacological / pharmacological treatments will be self-reported : ER consultations, specialist consultations, laboratory tests, new hospital stay, rehabilitation resource consumption

Time frame: At 12 (±7) and 36 (±3) months after hospitalization

Acceptable symptom state (questionnaire self-administered on ComPARe IT dedicated platform)

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Anchor questions ( 2 questions)

Time frame: 12(±7) and 36 (±3) months after the first day of the first hospitalization.

Health-related quality of life (questionnaire self-administered on ComPARe IT dedicated platform)

EuroQol : ED-5D-5L (5 themes of questions + a scale from 0 to 100, 100 is the best state of health)