There is still no consensus on whether drain fluid amylase (DFA) level, C-reactive protein (CRP) level, or complex scores predict clinically relevant postoperative pancreatic fistula (CR-POPF). The aim of this study is to determine the accuracy of simple biochemical parameters (leucocytes, neutrophils, lymphocytes, Neutrophil to Lymphocytes Ratio (NLR), at postoperative days 1 and 3) to exclude the diagnosis of CR-POPF.
From January 1, 2012 to December 31, 2020, consecutive patients underwent PD performed at Institut Paoli-Calmettes for various pathologies. Data were entered prospectively into a clinical database (NCT02871336). The cohort was split into 3 groups: * a training cohort ; * an internal validation cohort (Paoli Calmettes institute); * an external validation cohort (Rennes Pontchaillou Hospital).
Study Type
OBSERVATIONAL
Enrollment
648
A pancreaticogastrostomy or -jejunostomy duct-to-mucosa was achieved according to the surgeon's preference and pancreatic texture.
Incidence of clinically relevant pancreatic fistula
Clinically relevant postoperative pancreatic fistula according to the 2016 International Study Group of Pancreatic Surgery definition
Time frame: at hospital discharge assessed up to 30 days
Biological markers
Identification of biological markers to exclude clinically relevant postoperative pancreatic fistula
Time frame: Postoperative day one and three
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