Dextrose Effect on Postoperative Nausea and Vomiting (PONV)

Assiut University120 enrolled

Overview

The aim of this study to assess which time and dose of dextrose solution more effective in decreasing postoperative nausea and vomiting.

All patients signed informed consent after excluding patients not candidate for the study.patients were divided to three groups, taking either 0.9% saline as control group(group C), dextrose 5%(group D5) or dextrose 10%(group D10).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

120

Conditions

Postoperative Nausea and Vomiting

Interventions

Dextrose 5% in waterOTHER

One hour before operation, patients were given dexrose 5%100/hour only for 2 hours to end at about middle of surgery

Dextrose 10%OTHER

One hour before operation, patients were given dexrose 10 %100/hour only for 2 hours to end at about middle of surgery

Saline placeboOTHER

One hour before operation, patients were given normal saline100/hour only for 2 hours to end at about middle of surgery

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female non-smokers adults (age 18-65 years) * ASA I-II who were listed for elective surgery under general anesthesia (surgery which is risk for PONV). Exclusion Criteria: * Severe hypertension * Coagulopathy * Significant hepatic or renal disease * Diabetes mellitus or abnormal blood glucose on the morning of surgery * Withdrawal of consent * Severe intraoperative hypotension requiring large volume intravascular fluid treatment * Protocol violations including nitrous oxide administration.

Locations (1)

Assiut university hospital

Asyut, Assuit, Egypt

Outcomes

Primary Outcomes

Postoperative nausea and vomiting within 24 hour

Number of participants who experienced PONV grade ≥2 as assessed by PONV score . The PACU nurses assessed and documented PONV using a Verbal Descriptive Scale, which correlates to visual analog nausea scores, with an objective measure of severity: 0 = no PONV: patient reports no nausea and has had no emesis episodes; 1 = mild PONV: patient reports nausea but declines antiemetic treatment; 2 = moderate PONV: patient reports nausea and accepts antiemetic treatment; and 3 = severe PONV: nausea with any emesis episode (retching or vomiting). The score was obtained at 0, 30, 60, 90, and 120 minutes after PACU arrival; thus 5 scores were recorded during PACU stay. A 24-hour PONV assessment that elicited any nausea and emesis episode since PACU discharge was obtained by a blinded investigator by telephone or in person at the patient's bedside (delayed PONV).

Time frame: 24hour after surgery

Secondary Outcomes

Number of doses of antiemetics required to control PONV.

Frequency of doses of antiemetics required to control postoperative nausea and vomiting, initial antiemetic treatment was 10 mg slow IV metoclopramide for occurred nausea or 4 mg IV ondansetron for occurred nausea \& vomiting or if the previous treatment failed for nausea

Time frame: 24hour postoperative

Number of classes of antiemetics

Frequency of classes of antiemetics required to control postoperative nausea and vomiting, Initial antiemetic treatment was 10 mg slow IV metoclopramide for occurred nausea or 4 mg IV ondansetron for occurred nausea \& vomiting or if the previous treatment failed for nausea

Time frame: 24 hour postoperative

Data from ClinicalTrials.gov

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