Research Project: Pilot Study on Oral Urea Use in Patients at High Risk of Kidney Stone Recurrence

Centre hospitalier de l'Université de Montréal (CHUM)

Overview

In clinical practice, many patients are not able to modify their habits to achieve a high level of diuresis and fluid intake and therefore are at an elevated risk for stone recurrence. The investigators think that Ure-Na (osmotic agent) taking could help to increase urine volume and decrease urine concentration, which would be of benefit in the prevention of kidney stones.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Conditions

Kidney Stone

Interventions

Ure-NaDRUG

* Participants in the study will receive Oral Urea (Ure-Na) treatment at a dose of 30 grams per day (2 x 15 gram pouches per day) * Treatment will continue for approximately 1 month.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 to 60 years of age * High risk for recurrence (1 or more of) Bilateral or complex stones, Recurrent stones, Family history (1st degree relative), Non-calcium stones, Solitary kidney or anatomical abnormality, Nephrocalcinosis, Systemic disease with risk of stones (tubular acidosis, cystinuria, etc.) * Diuresis \< 1.8 L/24 hours despite recommendations from physicians and/or nutritionist at the kidney stone clinic (as documented in the previous 6 months) Exclusion Criteria: * Patient does not meet 1 of the 3 inclusion criteria * Pregnancy or breastfeeding * Lack of understanding about the protocol and effects of Ure-Na * Expected inability to adequately increase fluid intake on Ure-Na

Locations (1)

Centre Hospitalier de l'Université de Montréal (CHUM)

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Change From Baseline in urine output at 1 week and 1 Month

variation in 24-hour diuresis and urine biochemistry

Time frame: 1 week and 1 month

Data from ClinicalTrials.gov

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