Myocardial infarction (MI), as one of the many complications of COVID-19, is one of the contributing patients of patients' death. This study attempts on developing an intervention of MI by regenerating damaged cardiomyocytes due to insufficiency of oxygen in cardiac muscles, triggered by an occlusion of coronary artery (MI). Heart patch developed from amnion bilayer seeded with amnion epithelial stem cells and patient's autologous cardiomyocytes is used as a therapy. Patients who undergo bypass (CABG) surgery are given heart patch, and then patients condition are observed by ECG, Echo, blood test, and radiology (technetium-99m)
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
10
heart patch is seeded with patient's cardiomyocytes (taken from patient's heart waste tissue when undergoing bypass surgery) and stock amnion epithelial stem cells (HLA-DR negative to eliminate risk of rejection)
RSUPN dr. Cipto Mangunkusumo
Jakarta, DKI Jakarta, Indonesia
RECRUITINGRumah Sakit Universitas Indonesia
Depok, West Java, Indonesia
NOT_YET_RECRUITINGPusat Jantung Nasional Harapan Kita
Jakarta, Indonesia
NOT_YET_RECRUITINGChange of the ischemic burden (%)
Diagnosed by MRI
Time frame: Comparison from the imaging within 3 months before intervention, and after 6 months post treatment.
Change in the regional heart wall motion abnormality
measured using Echocardiographic
Time frame: Observation of the heart wall motion by 1 week before intervention and 4 - 12 - 24 weeks after intervention
Change of the electrocardiographic wave
Measured using electrocardiogram
Time frame: Observation of electrocardiogram records by 1 week before intervention and 4 - 12 - 24 weeks after intervention
Change of the ejection fraction
Measured using echocardiography
Time frame: Observation of the heart motion by 1 week before intervention and 4 - 12 - 24 weeks after intervention
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.