Randomized Clinical Trial of Standard FMT Treatments

Inclusion Criteria: 1. Male and female subjects 18 years of age or older. 2. Sexually active male and female subjects of childbearing potential agree to use an effective method of birth control during the study. 3. Female subjects of childbearing potential will be asked if they could be pregnant. If the subject is unsure a pregnancy test will be completed 4. Subject/LAR willing and able to provide informed consent. 5. Able to follow study procedures and complete the follow-up questionnaire for safety. 6. Subject must have an attending physician who will provide non-transplant care (Either PI of this study or referring physician). 7. Medical history of ≥ 3 bouts of CDI in outpatient or ≥ 2 bouts of CDI in inpatient with either group having ≥ 2 positive fecal tests for C. difficile toxin and at least one bout of CDI within 6 months of enrollment. 8. Received at least two courses of standard-of-care antibiotic therapy for CDI. Exclusion Criteria: 1. Unable to take capsules orally. 2. Requiring systemic non-C. difficile antibiotic therapy within 14 days prior to FMT. 3. Unwilling to stop taking non-dietary probiotics 24-96 hours prior to FMT. 4. Unable to stop taking bile acid sequestrants (e.g. cholestyramine) 24-96 hours prior to FMT. 5. Unable to stop use of drugs with CDI activity: oral vancomycin, oral or IV metronidazole, fidaxomicin, rifaximin or nitazoxanide 24-96 hours prior to FMT and after FMT. 6. Receipt of CDI monoclonal antibodies as treatment for the most recent bout of CDI. 7. Life expectancy of \< 6 months. 8. In the opinion of investigator, subject for any reason, should be excluded from the study.