The purpose of this study is to determine whether treatment with Dapagliflozin (DAPA) for 6 months will improve pulmonary capillary wedge pressure (PCWP) during exercise in heart failure/preserved ejection fraction (HFpEF) and improve cardiac metabolism.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
38
10 mg orally once a day
Taken orally once a day, the placebo looks identical to the study drug but it contains no active ingredient
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Pulmonary Capillary Wedge Pressure (PCWP) at Maximal Exercise
Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during exercise.
Time frame: Baseline, 24 weeks
Pulmonary Capillary Wedge Pressure (PCWP) at Rest
Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during rest.
Time frame: Baseline, 24 weeks
Change in Body Weight
Change in body weight as measured in kilograms (kg)
Time frame: Baseline, 24 weeks
Change in Total Blood Volume
Total blood volume was assessed using a radiolabeled iodinated albumin (131I, 5-25 μCu) indicator dilution technique with the BVA-100 Blood Volume Analyzer. Measured in millimeters (mL)
Time frame: Baseline, 24 weeks
Change in Plasma Volume
Plasma volume was assessed using a radiolabeled iodinated albumin (131I, 5-25 μCu) indicator dilution technique with the BVA-100 Blood Volume Analyzer. Measured in millimeters (mL)
Time frame: Baseline, 24 weeks
Change in Right Atrial (RA) Pressure at Maximal Exercise
Right Atrial (RA) pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during exercise.
Time frame: Baseline, 24 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Change in Right Atrial (RA) Pressure at Rest
Right Atrial (RA) pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during rest.
Time frame: Baseline, 24 weeks
Change in Mean Pulmonary Arterial Pressure (PA) at Maximal Exercise
Pulmonary Arterial (PA) pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during exercise.
Time frame: Baseline, 24 weeks
Change in Mean Pulmonary Arterial Pressure (PA) at Rest
Pulmonary Arterial (PA) pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during rest.
Time frame: Baseline, 24 weeks