The investigators conduct a study to evaluate the underlying causes of preeclampsia in oocyte-donation pregnancies.
A detailed medical history, questionnaires as well as blood, urine and placental samples will be used to analyse several factors leading to the high risk of preeclampsia in oocyte-donation pregnancies.
Study Type
OBSERVATIONAL
Enrollment
1,000
Experimental and Clinical Research Center (ECRC)
Berlin, Germany
RECRUITINGPreeclampsia in oocyte-donation pregnancies is caused by an altered composition of immune cells in placenta and blood.
T-Cell populations are altered in preeclampsia. HLA-mismatch of mother and donor oocyte lead to a "host-versus-graft" reaction. T-, B- and Natural killer cells are altered in placental tissue of oocyte-donation pregnancies.
Time frame: 01.01.2020 - 01.12.2025
Preeclampsia in oocyte-donation pregnancies is caused by an activation of pro-inflammatory factors and endothelial dysfunction.
Altered Natural killer cells and B-cells in oocyte-donation pregnancies lead to endothelial dysfunction. Pro-inflammatory factors are higher in OD pregnancy and can be measured in placental tissue via single-cell sequencing.
Time frame: 01.01.2020 - 01.12.2025
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