the Effect of Endometrial Compaction Caused by Progesterone Effect on Pregnancy Outcomes

Akdeniz University205 enrolled

Overview

The purpose of this prospective cohort study is to assess the effect of endometrial compaction caused by progesterone effect on pregnancy outcomes

For a pregnancy to occur, the embryo must implant in a receptive endometrium during the window of implantation, which is thought to occur from day 22 to 24 of an idealized 28-day cycle. Early studies have suggested that assessing endometrial thickness with the use of ultrasound may be an alternative to invasive techniques such as endometrial biopsy for attempting to determine a receptive endometrium for frozen-thawed embryo transfer (FET). A preovulatory endometrial thickness of 7 mm or more is considered to be the cutoff for endometrial receptivity, below which many physicians would cancel an embryo transfer. However, in most studies in the literature, endometrial thickness was measured either on the day of hCG in fresh embryo transfer cases or on the last day of estrogen treatment in thawed embryo transfers. There are a limited number of studies evaluating the luteal period, embryo transfer day and endometrial thickness. Accordingly, in this prospective cohort study is to assess the effect of endometrial compaction caused by progesterone effect on pregnancy outcomes

Study Type

OBSERVATIONAL

Enrollment

205

Conditions

Infertility Female Infertility Frozen-thawed Embryo Transfer

Interventions

ProgesteroneDRUG

ultrasound measurements of endometrial thickness at the end of the estrogen phase and the day of embryo transfer.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Woman aged 18-40 years 2. Presence of high quality (\>2BB) blastocyst 3. Hormonal(estrogen and progesterone) frozen- thawed embryo transfer cycles 4. presence of high quality blastocyst cryopreserved by vitrification method. 5. A single embryo transfer Exclusion Criteria: 1. Presence of uterine pathology 2. Participants whose optimal endometrial image cannot be obtained due to uterine position 3. Participants whose treatments were canceled for any reason before embryo transfer 4. Participants which had embryo transfer on the day 2 or 3 (at the cleavage stage) 5. Participants who had 2 embryo transfer 6. Presence of low quality (\<2BB) blastocyst 7. \> 15% loss of viability in the embryo during embryo thawing

Locations (1)

Akdeniz University

Antalya, Turkey (Türkiye)

Outcomes

Primary Outcomes

The change in endometrial thickness

changing in millimeters of endometrial thickness at the end of the estrogen phase and the day of embryo transfer.

Time frame: 1 year

ongoing pregnancy rates.

pregnancy beyond 12 weeks of gestational age.

Time frame: 1 year

Secondary Outcomes

The Correlation of Serum Progesterone Levels With the Degree of Endometrial Compaction on the Day of Frozen Embryo Transfer

comparison of progesterone levels and endometrial thickness

Time frame: On the day of frozen embryo transfer

Clinical pregnancy rate

6th week gestational age

Time frame: 6-7 weeks after the last menstrual period of the patient

Implantation rate

Percentage of gestational sacs compared to the number of embryos transferred

Time frame: 5 weeks after the last menstrual period of the patient

Clinical miscarriage

pregnancy loss after ultrasonographic detection of an intrauterine gestational sac

Time frame: after 5th gestational week

Data from ClinicalTrials.gov

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