Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke

Inclusion Criteria: 1. Aged 18 years or older; 2. Patient with acute ischemic stroke who is eligible for intravenous thrombolysis treatment within 4.5 hours of time last known well; 3. No significant prestroke functional disability: for age \<80 years, prestroke modified Rankin scale (mRS) ≤2; for age ≥80 years, prestroke mRS ≤1; 4. MCA-M1 or -M2, basilar artery, or posterior cerebral artery-P1 occlusion proved by CTA/MRA; 5. EVT is planned by clinical care team; 6. Written informed consent is obtained from patients and/or their legal representatives. Exclusion Criteria: 1. Intracranial hemorrhage on baseline CT or MR 2. Contraindication to intravenous thrombolytics 3. Already received intravenous thrombolytic after index stroke 4. Known pregnancy, or breastfeeding, or serum beta human chorionic gonadotropin test is positive on admission 5. Contraindication to radiographic contrast agents, nickel, titanium metals or their alloys 6. Current participation in another investigational drug clinical trial 7. Arterial tortuosity and/or other arterial disease that would lead to unstable access platform or prevent the thrombectomy device from reaching the target vessel 8. Patient with a preexisting neurological or psychiatric disease that would confound the outcome assessments 9. Patient with occlusions in two or more vascular territories (e.g. bilateral territories, or anterior and posterior circulation) 10. Mass effect or intracranial neoplasm on baseline CT or MR (except small meningioma) 11. Intracranial arteriovenous malformation or aneurysm on baseline CT or MR angiography 12. Any terminal disease with a life expectancy less than half a year 13. Unlikely to be available for follow-up at 90 days.