CORNEAL EPITHELIAL MAPPING IN DIABETICS

N/AActive Not RecruitingNCT04734158

Minia University153 enrolled

Overview

The corneal epithelium is the outermost layer that covers the front of the eye; it not only functions as a barrier that blocks the passage of foreign material, but also plays an important role in maintaining high optical quality. The stem cells in the basal layer of the limbal epithelium hold a physiological significance in the renewal and metabolism of corneal epithelium, particularly under stressful situations.

The cornea in diabetic patients suffers from cellular dysfunction and dysfunctional repairal mechanisms, which include recurrent erosions, delayed wound healing, ulcers, and edema. In addition and undoubtedly related to epithelial dysfunction, alterations in epithelial basement membrane occur.

Study Type

OBSERVATIONAL

Enrollment

153

Conditions

Cornea Epithelial Mapping

Interventions

corneal imagingOTHER

corneal imaging using AS-OCT

Eligibility

Sex: ALLMin age: 40 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. The patients aged between 40- 60 years old of both genders. 2. The patients in (Group A) should be diabetics for more than 10 years and free from any other systemic diseases with diabetic macular edema (by OCT). 3. The patients in (Group B) should be diabetics for more than 10 years and free from any other systemic diseases without diabetic macular edema (by OCT). 4. The patients in (Group C) should be free of any systemic diseases and normal macular thickness (by OCT) Exclusion Criteria: 1. Previous history of any intraocular surgery, intravitreal injection, laser or refractive surgery. 2. Ocular surface disorders (e.g. dry eye) or any corneal pathology. 3. Corneal scars or epithelial dystrophies. 4. Use of any topical medications. 5. Elevated IOP, pregnancy or lactation.

Locations (1)

Minia University

Minya, Egypt

Outcomes

Primary Outcomes

corneal epithelial thickness

corneal thickness in diabetics using OCT

Time frame: 2 years

Data from ClinicalTrials.gov

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