CPI-006 Plus Standard of Care Versus Placebo Plus Standard of Care in Mild to Moderately Symptomatic Hospitalized Covid-19 Patients

Inclusion Criteria: * Confirmed positive by polymerase chain reaction (PCR) or antigen test for SARS-CoV-2 with sample collection ≤ 10 days prior to randomization * Covid-19 illness of any duration of symptoms * Hospitalized for Covid-19 for ≤ 5 days with mild to moderate Covid-19 symptoms and meets criteria for either Category 4, Category 5, or Category 6 per 8-point ordinal scale * Adequate organ function * Participants of child-bearing age must agree to use adequate contraception for 6 weeks after study treatment administration Exclusion Criteria: * Signs of acute respiratory distress syndrome or respiratory failure necessitating mechanical ventilation at time of screening/randomization or anticipated need for mechanical ventilation * History of severe chronic respiratory disease and requirement for long-term oxygen therapy * Uncontrolled active systemic infection or hemodynamic instability requiring admission to an intensive care unit * Malignant tumor receiving treatment, or other serious systemic diseases affecting life expectancy within 29 days of screening * Receipt of cancer chemotherapy or immunomodulatory drugs during preceding 2 months (steroids for treatment of Covid-19 are acceptable) * Convalescent plasma (CCP) or anti-SARS-CoV-2 monoclonal antibodies administered \<24 hours prior to randomization. Must have recovered from any adverse events related to CCP treatment. Received chloroquine or hydroxychloroquine within last 7 days or during the study * Current participation in other clinical trials including extended access programs * Active deep vein thrombosis or pulmonary embolism within last 6 months * Anticipated discharge from hospital or transfer to another hospital which is not a study site within 48 hours of admission * Active uncontrolled co-morbid disease that may interfere with study conduct or interpretation of findings * Known to be positive for HIV or positive test for chronic HBV infection or positive test for hepatitis C antibody * Pregnancy or breast feeding