This study aims to compare the effects of dexmedetomidine and meperidine on the incidence of shivering in patients undergoing CABG.
Shivering is a common complication in the postoperative period. The incidence of shivering has been reported to range from 5% to 65% under general anesthesia and as 33% during epidural anesthesia. Shivering can increase perioperative risk in patients. Both dexmedetomidine and meperidine are effective agents for the prevention of postanesthetic shivering. However, few studies have compared the anti-shivering effects of different agents following coronary artery bypass graft (CABG). This study aims to compare the effects of dexmedetomidine and meperidine on the incidence of shivering in patients undergoing CABG.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
180
Dexmedetomidine would be intravenously infused at a dose of 1μg/kg over 15 minutes 30 min before the end of surgery
Meperidine would be intravenously injected at a dose of 0.5mg/kg 30 min before the end of surgery
Equal volume of normal saline to dexmedetomidine and meperidine group.
China, Shandong Qianfoshan Hospital
Jinan, Shandong, China
RECRUITINGThe incidence of postoperative shivering
The incidence and severity of postoperative shivering and the rescue treatment
Time frame: Within postoperative 24 hours
Times of postoperative rescue drugs used
Time frame: Within postoperative 24 hours
The incidence of postoperative hypotension and bradycardia
Time frame: From the administration of experimental drugs to postoperative 24 hours
Ramsay sedation score
The minimum and maximum score are 1 and 6, respectively. Score 1 represents that patients is anxious and agitated or restless , or both. And score 6 represents that patients exhibits no response.
Time frame: Within postoperative 3 days
Postoperative extubation time
Time frame: The time of extubation
Length of stay in the ICU
Time frame: The length of stay in ICU within postoperative 30 days
The incidence of postoperative delirium
Time frame: Within postoperative 7 days
The incidence of postoperative arrhythmias
Time frame: Within postoperative 24 hours
The incidence and severity of postoperative PONV
Time frame: Within postoperative 3 days
Length of stay
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Time frame: The first day after surgery to discharge
The rate of all-cause death of participants
Time frame: Within postoperative 30 days