Identification of a bacterial signature in the blood or stool that may be associated with acute rejection in patients treated with Nulojix during their first year of transplant.
Gut microbiota as well as the signature of the 16S plasma bacterial DNA and bacterial metabolites of patients on the date of transplantation and during the first year after transplantation will be analyzed. The phenotype of the patients' T lymphocytes will be analyzed at the same time. These data will be correlated with the occurrence of acute cell rejection during the first year of transplantation
Study Type
OBSERVATIONAL
Enrollment
70
Drugs administrated are part of the usual care
Nephrologie transplantation CHRU Besançon
Besançon, France
Néphrologie, hémodialyse, aphérèses, transplantation rénale
La Tronche, France
Nephrologie transplantation CHRU Nantes
Nantes, France
Acute rejection occurence
Occurence of cellular rejection according to the BANFF 2017
Time frame: 1 year or rejection
Gut and circulating microbiota
16S DNA sequencing
Time frame: 1 year or rejection
Lymphocyte phenotype
CD3+CD4+CD57+PD1-, CD3+CD8+CD28low, CD3+CD8+CD45RA phenotype
Time frame: 1 year or rejection
Glomerular filtration rate
CDK-EPI creatinine equation
Time frame: 1 year or rejection
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Service de néphrologie et transplantation adulte. Hôpital Necker
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