Replication of the EINSTEIN-DVT Anticoagulant Trial in Healthcare Claims Data

Criteria: Please see https://drive.google.com/drive/folders/1WD618wrywYjEaXzfLTcuK-VCcnb6b-gV for full code and algorithm definitions. Inclusion Criteria: \- Confirmed acute symptomatic proximal DVT without symptomatic PE Exclusion Criteria: * Age ≤ 18 * Thrombectomy, insertion of a caval filter, or use of a fibrinolytic agent to treat the current episode of DVT or PE two weeks prior to and including day of enrollment * Other indications for VKA than DVT and/or PE six months prior to and including day of enrollment * Any of the following six months prior to and including day of enrollment: * Creatine clearance \< 30 ml/min * Significant liver disease (e.g. acute hepatitis, chronic active hepatitis, cirrhosis) or ALAT\>3 ULN * Bacterial endocarditis * Active bleeding or high risk for bleeding contraindicating treatment with enoxaparin or VKA * Systolic blood pressure \> 180 mgHg or diastolic blood pressure \> 110 mgHg * Childbearing potential without proper contraceptive measures, pregnancy, or breastfeeding * Life expectancy \< 3 months in the last year prior to and including day of enrollment * Concomitant use of strong CYP3A4 inhibitors (e.g. HIV protease inhibitors, systemic ketoconazole) or strong CYP3A4 inducers two weeks prior to and including day of enrollment * Symptomatic pulmonary embolism two weeks prior to and including day of enrollment