Guselkumab (Anti-IL 23 Monoclonal Antibody) for Alcohol Associated Liver Disease

Inclusion Criteria: 1. Able to provide written informed consent (either from patient or patient's legally acceptable representative) 2. Male or female patients 21 years of age or older with BMI ≥ 20 to ≤ 45 kg/m2 3. Patients with moderate alcohol use disorder (AUD) as defined by the AASLD Practice Guidance to have ≥ 4 symptoms out of 11: 1. Alcohol is often taken in larger amounts and/or over a longer period than the patient intended. 2. Persistent attempts or one or more unsuccessful efforts made to cut down or control alcohol use. 3. A great deal of time is spent in activities necessary to obtain alcohol, use alcohol, or recover from effects. 4. Craving or strong desire or urge to use alcohol 5. Recurrent alcohol use resulting in a failure to fulfill major role obligations at work, school, or home. 6. Continued alcohol use despite having persistent or recurrent social or interpersonal problem caused or exacerbated by the effects of the alcohol. 7. Important social, occupational or recreational activities given up or reduced because of alcohol use. 8. Recurrent alcohol use in situations in which it is physically hazardous. 9. Alcohol use is continued despite knowledge of having a persistent or recurrent physical or psychological problem that is likely to have been caused or exacerbated by the alcohol. 10. Tolerance, as defined by either of the following: <!-- --> 1. Markedly increased amounts of the alcohol in order to achieve intoxication or desired effect 2. Markedly diminished effect with continued use of the same amount k. Withdrawal, as manifested by either of the following: 1. The characteristic alcohol withdrawal syndrome or 2. Alcohol (or a closely related substance) is taken to relieve or avoid withdrawal symptoms 4. Evidence of end-organ damage to the liver as defined by a. MRI-PDFF ≥ 8% suggestive of significant hepatic accumulation of triglyceride within 3 months of screening; if patients cannot get an MRI, CAP ≥ 300dB/m 5. Consumed alcohol within 12 weeks of entry into the study, AND a. AST and ALT less than 200 U/L AND 6. No evidence of active infection as determined by the investigator. 7. Women of child-bearing potential (defined as females who are not surgically sterile or who are not over the age of 52 and amenorrheic for at least 12 months) must utilize appropriate birth control throughout the study duration. Acceptable methods that may be used are abstinence, birth control pills ("The Pill") or patch, diaphragm, intrauterine device (IUD/ coil), vaginal ring, condom, surgical sterilization or progestin implant or injection, or sexual activity limited to a sterile (e.g., vasectomized) male partner. 8. Male patients must agree to use a medically acceptable method of contraception/birth control throughout the study duration. Exclusion Criteria: 1. History or evidence of other or concomitant cause(s) of liver disease as a result of: 1. Autoimmune liver disease 2. Wilson disease (ceruloplasmin levels \< 10 mcg/L) 3. Vascular liver disease 4. Drug induced liver disease 5. Surface antigen positive hepatitis B (HBsAg+). Note: patients with isolated core antibody (HBcAb) are not excluded. 6. Acute hepatitis A 7. Acute HCV or chronic hepatitis C with a history of decompensated cirrhosis. (Note: patients with stable chronic Hep C Virus (HCV) or successfully treated HCV are not excluded. Anti-HBc antibody positive patients will be given a prophylaxis with entecavir 0.5mg PO once daily, starting one week prior to start of guselkumab to 6 months after the last dose of guselkumab) 2. Noninvasive criteria to exclude cirrhosis: 1. MRE ≥ 3.63 kPa; if MRE not available, VCTE ≥ 16 kPa 2. FIB-4 ≥ 2.67 3. Imaging evidence of varices, splenomegaly, ascites, or shrunken cirrhotic liver 3. Co-infection with human immunodeficiency virus (HIV) 4. History or evidence of positive Urine Drug Screen (amphetamines, barbiturates, benzodiazepines, cocaine and opiates) except THC and legal prescription medications. 5. Any active malignancies other than curatively treated skin cancer (basal cell or squamous cell carcinomas) or any other malignancy diagnosed within the last five years 6. History or evidence of active tuberculosis 7. Positive Quantiferon test 8. Significant systemic or major illness other than liver disease, including coronary artery disease, cerebrovascular disease, pulmonary disease, renal failure, serious psychiatric disease, that, in the opinion of the Investigator would preclude the patient from participating in and completing the study 9. Patients requiring the use of vasopressors or inotropic support. 10. Any patient that has received any investigational drug within 30 days of dosing or who is scheduled to receive another investigational drug at any time during the study 11. Patients who are taking drug products that are primarily the substrates of CYP2C8, such as chloroquine, paclitaxel, rosiglitazone, repaglinide 12. If female, known pregnancy, or has a positive serum pregnancy test, or is lactating/breastfeeding 13. Serum creatinine \> 1.5 mg/dL 14. Patients who have had organ transplantation (such as liver, kidney, lung, heart, bone marrow, or stem cell etc.), other than cornea transplant 15. Presence of cirrhosis on imaging or any of following lab parameters: 1. Albumin \< 3.7 g/dL 2. Direct bilirubin \> 0.5 mg/dl unless due to Gilbert's syndrome 3. Platelets \< 140K 4. INR \> 1.3 16. Presence of any features of portal hypertension such as ascites, history of ascites or varices, or encephalopathy 17. Previous use of guselkumab ( or another IL-23 inhibitors) or hypersentivity to guselkumab 18. Previous history of skin cancers in the last one year 19. Previous history of breast or prostate cancer or any cancer within the last 5 years