The objective of this study was to investigate the improving effect of corneal disorder in primary open-angle glaucoma and ocular hypertension patients, when switched from the 0.005% latanoprost ophthalmic solution (one drop at a time, once daily) to the 0.0015% tafluprost ophthalmic solution (one drop at a time, once daily). Efficacy also was investigated.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
1
latanoprost 0.05%(one drop, once daily)
tafluprost 0.015% (one drop, once daily)
Chi Mei Hospital Liouying Branch
Tainan, Taiwan
Efficacy: Changes in the Intraocular Pressure (IOP) at each visit
Tonometer
Time frame: 3 months
Safety:Changes in the fluorescein staining score (NEI) at Visit 2
fluorescein staining
Time frame: 3 months
Changes in the fluorescein staining score (NEI) at Visit 1
fluorescein staining
Time frame: 1 months
Changes in ocular symptoms (irritation/burning/stinging, foreign body sensation, tearing, itching and dry eye sensation) at each visit
Questionnaire
Time frame: 3 months
Changes in the Tear Break-Up Time (TBUT) at each visit
slit-lamp
Time frame: 3 months
Changes in the hyperaemia at each visit
slit-lamp
Time frame: 3 months
Treatment compliance
Questionnaire
Time frame: 3 months
Concomitant medication
Questionnaire
Time frame: 3 months
Patient satisfaction about test medication
Questionnaire
Time frame: 3 months
Usability of eyedrop bottle
Questionnaire
Time frame: 3 months
Adverse drug reactions
Questionnaire
Time frame: 3 months
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