NOCDURNA PASS Study Using Registries in Denmark, Germany and Sweden

Incidence rate of hyponatraemia requiring hospital intensive care

Hyponatraemia requiring hospital intensive care was defined as a primary or secondary diagnosis of hyponatraemia recorded in an intensive care unit.

Time frame: Through study completion, typically 2 months

Incidence and severity of clinically significant hyponatraemia

Clinically significant hyponatraemia was defined as a serum sodium concentration of \<130 mmol/L. Severity of hyponatraemia was categorized as mild hyponatraemia (serum sodium concentration: 130 to \<135 mmol/L), moderate hyponatraemia (serum sodium concentration: \>125 to \<130 mmol/L) and severe hyponatraemia (serum sodium concentration: less than equal to \[≤\]125 mmol/L).

Time frame: Through study completion, typically 2 months

Rate of all-cause mortality

All-cause mortality was defined as death from any cause.

Time frame: Through study completion, typically 2 months

Incidence rate of major adverse cardiovascular events (MACE)

Major adverse cardiovascular events were defined as a record of myocardial infarction and stroke. Fatal and non-fatal events will be considered separately.

Time frame: Through study completion, typically 2 months

Incidence rate of major venous thromboembolic events (VTEs)

Venous thromboembolic events were defined as a record of a deep vein thrombosis, pulmonary embolism or portal vein thrombosis. Fatal and non-fatal events will be considered separately.