Airway Clearance for Pediatric and Adult Cystic Fibrosis Patients Using a Portable Intra-Pulmonary Percussion Device

Inclusion Criteria: * Ages 6-21 years * Cystic fibrosis stable by physician assessment * Assents to forego additional experimental treatments during the study * Currently using and familiar with airway clearance therapy for treatment of cystic fibrosis * Participant (or parent or legal guardian if the participant is a minor) is willing to provide -----Informed Consent Exclusion Criteria: * FEV1 \< 40% predictive * Pneumothorax * Hemoptysis * Coronavirus disease (COVID) 19 diagnosis within last 14 days * Any condition that, in the opinion of the investigator, would interfere with the study conduct or the safety of the participant * Additional Exclusion Criteria: Outpatient Arm (in addition to general exclusion criteria above) Decrease in FEV1 \> 10% from baseline over last 12 months Antibiotic Initiation for acute CF exacerbation Hospitalization for CF Exacerbation * Additional Exclusion Criteria: Inpatient Arm (in addition to general exclusion criteria above) Failure to increase FEV1 \> 10 % from initial Pulmonary function testing (PFTs) on admission by day 9 of hospitalization.