RSV Burden in Outpatient Settings

Association Clinique Thérapeutique Infantile du val de Marne3,500 enrolled

Overview

Strengthening outpatient low respiratory tract infection surveillance to document the burden of Respiratory Syncytial Virus (RSV)

The study protocol is designed with three key components: 1. Build on existing PARI outpatient syndromic surveillance by adding laboratory multiplex testing of LRTI samples (RSV, Influenza, SARS-COV-2) 2. Follow all bronchiolitis through the PARI RWE database and document "patient journey" for 5 years after first medical visit 3. Review the electronic PARI data of three previous seasons in order to document the impact of LRTI attributable to RSV in children \< 2 years in France prior to enhanced surveillance

Study Type

OBSERVATIONAL

Enrollment

3,500

Conditions

RSV Infection Children, Only Outpatient Bronchiolitis Otitis Media Pneumonia

Interventions

nasopharyngeal samplesDIAGNOSTIC_TEST

rapid antigen test for Sars Cov-2, influenza and RSV. multiplex RT-PCR for a subgroup of 500 patients

Eligibility

Sex: ALLMin age: 1 DayMax age: 24 Months

Medical Language ↔ Plain English

Inclusion Criteria: * children under 24 months of age (≤) * One of the holders of parental authority signed the consent * Patient affiliated to a social security scheme (Social Security or Universal Medical Coverage) * First episode of bronchiolitis defined by * Age ≤24 months * At least one symptom from group A and one symptom from group B Group A (one or more) * Fever \>38 °C * Cough * Otalgia * Nasal congestion * Rhinorrhea * Coryza * Dysphagia Group B (one or more) * whistling * Crackles * Rales * Decrease in respiratory noise * Shortness of breath * Dyspnea * OR Acute purulent otitis media (Paradise Criteria) or otorrhea. * OR Pneumonia defined by the presence of opacity of parenchymal condensation and/or pleural effusion on chest X-ray associated with fever Exclusion Criteria: * Age \>24 months * Refusal by one of the parents * Not affiliated to a social security system

Locations (1)

ACTIV

Créteil, France

RECRUITING