Appropriate gestational weight gain (GWG) is a key factor in balancing maternal and neonatal needs of nourishment and health, which is especially important in women with gestational diabetes mellitus (GDM). However, there are no specific guidelines for GWG in Chinese pregnant women and even for GDM pregnant women.This project intends to fill in the gaps of this field through multi-center large sample prospective cohort study.
Inappropriate gestational weight gain (GWG) is an important risk factor affecting adverse pregnancy outcomes. However, the current guidelines for GWG are based on American population and may not apply to pregnant women in China, especially for those with gestational diabetes mellitus (GDM) who have high risk factors. The big gaps in academic-related fields need to be filled. Our research group has previously found the heterogeneous relationships between GWG and adverse outcomes in GDM women with different abnormal glucose metabolism. Therefore, based on the principles of precision medicine, this project intends to establish for the first time the GWG standard for Chinese pregnant women to optimize the GWG management through a multicenter prospective cohort study. At the same time, specific GWG guidelines applicable to GDM women with different glucose metabolism abnormalities were innovatively constructed. Our study will provide strong evidence for stratified management and precise intervention of GDM pregnant women, which is of great significance to ensure health of both mothers and their offspring.
Study Type
OBSERVATIONAL
Enrollment
10,000
Women's Hospital School of Medicine Zhejiang University
Hangzhou, China
RECRUITINGMaternal outcomes
Including pregnancy-induced hypertension, preterm delivery, abortion, delivery way and so on. They are diagnosed by clinicians and the data is gathered from medical records.
Time frame: Through delivery completion, up to 40 weeks
Neonatal outcomes
Birth weight(in gram), birth height (in centimetre), gestational week (in week) and so on. They are diagnosed by clinicians and the data is gathered from medical records.
Time frame: Through delivery completion, up to 40 weeks
glucose metabolism index
OGTT results (mmol/L), HbA1c (%) and so on
Time frame: postpartum 42 days
offspring
weight (in gram), height (in centimetre), feeding situation (breast feeding or artificial feeding) and so on.
Time frame: postpartum 42 days
annual follow-up results
Annual questionnaire and physical examination, including weight (in kilogram), height (in metre), disease history, diet surveys and so on.
Time frame: 1 or 2 years after delivery
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