Optical Coherence Tomography Guided Laser Treatment of Basal Cell Carcinoma

Christopher Zachary40 enrolled

Overview

Optical coherence tomography guided laser treatment of basal cell carcinoma

The purpose of this pilot study is to examine the treatment basal cell carcinoma (BCC) with laser technology under the guidance of optical coherence tomography imaging (OCT). The laser modality that we plan to use is the long-pulse Nd:YAG 1064nm laser, which is a non-ablative laser already shown to effectively treat BCC. Laser treatment of BCC has limited precedent in the literature, but the addition of OCT has the opportunity to enhance outcomes by better targeting the treatment and permitting more precise monitoring of clearance. We propose to use OCT imaging to guide the laser treatment to achieve optimal efficacy with minimized side-effects.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Basal Cell Carcinoma Superficial Basal Cell Carcinoma Nodular Basal Cell Carcinoma

Interventions

1064 nm long-pulse Nd:YAG laserDEVICE

BCC lesion will be treated with long-pulse 1064 laser, with surface temperature monitored by infrared camera.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Ability to understand and carry out subject instructions or be represented by a legally authorized guardian or representative * Ages 18 and older * Seeks and is scheduled for treatment of a BCC previously confirmed with biopsy Exclusion Criteria: Any of the following will exclude participation in the study: * Inability to understand and/or carry out instructions * Patients with a BCC lesion that requires excision. This would include relatively large lesions (\>2.5 cm diameter), lesions that penetrate deep into the skin beyond the depth of the OCT image capture, high risk lesions as defined by the American Academy of Dermatology as recurrent and sclerosing subtype BCC, or metastases. * Patients with periocular BCCs which might expose the patient to risk of damage to eyes from the laser. * BCCs on legs due to their tendency towards poor wound healing. * Pregnancy * Patients unable to follow-up for the full 12 months.

Locations (1)

UCI Health Gottschalk Medical Plaza

Irvine, California, United States

RECRUITING

Outcomes

Primary Outcomes

Complete clearance of BCC lesion

Those whose lesion is not in a cosmetically sensitive area will undergo a skin biopsy for histological confirmation of OCT results.

Time frame: 1 year

Secondary Outcomes

Cosmetic outcome

We assess cosmetic outcome and any adverse effects of the laser treatment as a result of the laser treatment, rated on a 0-4 Likert scaleworst cosmetic outcome and 4 resembling normal skin, upon follow-up of treatment.

Time frame: 1 year

Central Contacts

Feben Messele

CONTACT

949-824-5515 fmessele@hs.uci.edu

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.