Efficacy and Safety of Auto-FMT in Preventing aGVHD

The First Affiliated Hospital of Soochow University100 enrolled

Overview

To evaluation the efficacy and safety of autologous fecal bacteria transplantation in preventing acute graft versus host disease after haploidentical hematopoietic stem cell transplantation. Bone marrow transplant patients were recruited.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

100

Conditions

Graft Versus Host Disease, Acute

Interventions

autologous fecal bacteriaOTHER

autologous fecal bacteria transplantation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Haplo-HSCT patients; Bacteroidetes \>0.1%; inverse Simpson diversity ≥2 Exclusion Criteria: * Gastrointestinal diseases；Age\>60; or Age\<10；Probiotics or prebiotics were taken before enrollment

Locations (1)

Ye Zhao

Suzhou, Jiangsu, China

RECRUITING

Outcomes

Primary Outcomes

Acute Graft-Versus-Host Disease

Time frame: 90 days after haploidentical hematopoietic stem cell transplantation

Secondary Outcomes

overall survival

Time frame: 90 days after haploidentical hematopoietic stem cell transplantation

Event free survival

Time frame: 90 days after haploidentical hematopoietic stem cell transplantation

Data from ClinicalTrials.gov

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