Quantification of Abdominal Organ Motion Using MRI

The Christie NHS Foundation Trust23 enrolled

Overview

The primary aim of the study is to quantify abdominal motion in order to optimise MR imaging. The study will compare three-motion management strategies a) free-breathing, b) using an abdominal compression belt and c) using MRI-compatible visually guided breath-holds.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cancer

Interventions

Compression beltDEVICE

The abdominal belt is fastened around the lower abdomen and inflated (like an inner tube) to apply pressure to the belly and reduce the motion associated with respiration (breathing)

Visual Guided Breath-holdOTHER

A small tracer will be place on the lower abdomen that will feedback to a computer screen that will have graphics to show you if the participant is in breath-hold or not.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Healthy volunteers * 18 years or older, * no MRI contra-indications * must agree to registration as a non-patient in CWP (the local electronic healthcare records system) and have their MRIs read and reviewed for incidental findings by a clinical radiologist Patient Volunteers * undergoing radiotherapy to the abdominal region at the Christie NHS Foundation Trust * Over 18 years of age Exclusion Criteria: * Any contraindications to MRI identified after MRI safety screening including completion of an MRI Safety Screening Form * Unable to tolerate MRI scan * Pregnancy * Colostomy

Locations (1)

The Christie NHS Foundation Trust

Manchester, Greater Manchester, United Kingdom

Outcomes

Primary Outcomes

MRI Motion Management SOP

Development and implementation of an MRI protocol suitable for organ motion characterisation for the abdomen. Determination of the benefit of motion management strategies for abdominal radiotherapy.

Time frame: through study completion, approximately 6 months

Secondary Outcomes

Quantification of motion

Quantification of intra-abdominal inter and intra-fraction motion with and without abdominal compression and visually guided breath holds using MR imaging. Comparative analysis of comparable treatment plans with and without abdominal compression and visually guided breath holds on relevant treatment planning software for PBT and MRL. Development of process to evaluate patient compliance when using a commercial available abdominal compression belt and visually guided breath-hold.

Time frame: through study completion, approximately 6 months

Data from ClinicalTrials.gov

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