It is already known that the risk of preterm labor in twin pregnancy before 37 week is 8-9 fold higher compared to singletons, and progesterone supplementation can decrease the incidence of preterm labor in singleton pregnancy. There were studies that used 200mg vaginal progesterone with no effect on the result So this study aims To examine the effect of prophylactic vaginal progesterone 400mg v.s 200mg for prevention of preterm birth in twin pregnancies
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
100
Taking prontogest vaginally
Ain Shams University Maternity hospital
Cairo, Egypt
Preterm labor
Number of participants which had preterm labor
Time frame: Before 37 weeks gestation
Cervical length changes
Cervical length changes in centimeters
Time frame: Between 14 weeks and 22 weeks gestation
Neonatal ICU admission
Number of neonates required neonatal ICU admission
Time frame: The first 28 days after delivery
Neonatal mechanical ventilation
Number of neonates required mechanical ventilation
Time frame: The first 28 days after delivery
Progesterone side effects
The number of patients experiencing progesterone side effects
Time frame: During one year which is the period from the start of the study till its end
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