Oxidative Stress Markers in COPD

Minia University70 enrolled

Overview

Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Role of Oxidative Stress in COPD

Interventions

oxidative stess markersOTHER

markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * 1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control Exclusion Criteria: * Patients of: 1. Acute exacerbation, at the time of the study, of COPD. 2. Any obvious abnormal lung parenchymal lesions. 3. Lung cancer. 4. Congestive heart failure. 5. current smokers 6. Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.

Locations (1)

Minia University Hospital

Multiple Locations, Minya Governorate, Egypt

Outcomes

Primary Outcomes

oxidative stress markers in non smokers COPD compared to healthy control

markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

Time frame: 1month

Data from ClinicalTrials.gov

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