Perioperative Troponin I and NT Pro-BNP in Lung Resection

Hospital Universitari Vall d'Hebron Research Institute475 enrolled

Overview

After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery. Integrating both cardiac biomarkers may improve the predictive value for cardiovascular complications after lung resection.

Objectives: To evaluate the incidence and magnitude of perioperative N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (Tn I) elevation in patients undergoing pulmonary resection and its predictive value for cardiovascular complications. Methodology: Prospective, multicenter, observational cohort study in patients \>45 years undergoing elective thoracic surgery for lung resection. Cardiac biomarkers Tn I and NT-proBNP will be measured preoperatively and at postoperative days 1 and 2. Risk score for major cardiovascular postoperative complications will be calculated depending of both biomarkers perioperative changes.

Study Type

OBSERVATIONAL

Enrollment

475

Conditions

Cardiac Ischemia Thoracic Cancer Complication,Postoperative

Interventions

serum high-sensitivity Troponin I (TnI) and NT-Pro-Brain Natriuretic Peptide (NT-proBNP)DIAGNOSTIC_TEST

Both biomarkers will be determined in each patient preoperatively and at postoperative day 1 and day 2.Measurements will not necessarily be taken independently of other measurements, meaning that the addition of the biomarker could be included in routine pre or postoperative day-1 and day 2 blood tests.

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥45 years old * Patients undergoing elective surgery for lung resection Exclusion Criteria: * Patients undergoing urgent, emergent, or nonthoracic surgery * Patients or family did not consent to participate * Presence of symptoms related with infection or sepsis * Patients with a documented history of severe heart failure and/or ejection fraction lower than 30%

Locations (1)

Hospital Universitari Vall d'Hebron

Barcelona, Spain

Outcomes

Primary Outcomes

NT-proBNP perioperative changes

Perioperative change in NT-Pro-Brain Natriuretic Peptide (NT-proBNP) levels in patients undergoing pulmonary resection. Cutt-of values will be NT-proBNP ≥ 300 pg/ml pg/ml

Time frame: Change from baseline NT-proBNP at two-days after surgery

TnI perioperative changes

Perioperative changes in high-sensitivity troponin I (TnI) levels in patients undergoing pulmonary resection. Cutt-of values will be TnI ≥45 ng/L

Time frame: Change from baseline TnI at two-days after surgery

Major cardiovascular complications

Postoperative non-fatal cardiac arrest, acute myocardial infarction, angina, congestive heart failure, new clinically relevant cardiac arrhythmia, cardiovascular death

Time frame: 30-days after surgery

Data from ClinicalTrials.gov

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