Exploration of pathophysiological mechanisms in chronic inflammatory rheumatism and rare systemic autoimmune diseases with the objective of identifying therapeutic targets.
The primary objective is to characterization of the quantitative and qualitative specificities of the different leukocyte sub-populations in patients with chronic inflammatory rheumatism and rare systemic autoimmune diseases. We will perform an exploratory descriptive study whom primary endpoint will be to assess by FACS the phenotype of the specific leukocyte subsets. In addition, we will characterize the protein and transcriptomic signature associated with the conditions for which we have obtained preliminary data showing their potential involvement in autoimmunity (i.e: IL7 pathway, IFN signature).
Study Type
OBSERVATIONAL
Enrollment
1,500
sampling of blood for research during routine care
CHU Bicêtre
Le Kremlin-Bicêtre, France
Characterization of the quantitative and qualitative specificities of the different leukocyte subpopulations in patients with chronic inflammatory rheumatism and rare systemic autoimmune diseases
Proportion of different leukocytes subset
Time frame: At the end of the study (5 years)
Protein study (ELISA on serum) : IL7
levels of IL7 and other cytokines
Time frame: At the end of the study (5 years)
Transcriptome study (RNA) : mRNA levels
assessement of different mRRNA involved in Il7/IFN pathways by molecular biology techniques (RNAseq, qPCR, nano string)
Time frame: At the end of the study (5 years)
Genomic study (DNA) : SNPs
Determination of the genotype of different SNPs involved in IL7/IFN pathways
Time frame: At the end of the study (5 years)
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