Microbiota and Allergy

Federico II University120 enrolled

Overview

Food allergy derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for gut microbiota in oral tolerance development. An altered composition of gut microbiota results in an unbalanced local and systemic immune response to food allergens. There are qualitative and quantitative differences in gut microbiota composition in children with food allergy. Preliminary results of MATFA study demonstrated gut microbiota in allergic children.These findings support the pivotal role of the gut microbiota in the pathogenesis of allergic diseases and may open new strategies in the development of innovative preventive and therapeutic approaches.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Allergy

Interventions

food allergyOTHER

food allergy

respiratory allergyOTHER

respiratory allergy

healthy controlsOTHER

healthy controls

Eligibility

Sex: ALLMin age: 48 MonthsMax age: 84 Months

Medical Language ↔ Plain English

Inclusion Criteria: * Children with sure diagnosis of food allergy, * children with sure diagnosis of respiratory allergy Exclusion Criteria: * age at enrollment \<48 months or \>84 months; * eosinophilic disorders of the gastrointestinal tract; * chronic systemic diseases; * congenital cardiac defects; * acute or chronic infections; * autoimmune diseases; * immunodeficiencies; * chronic inflammatory bowel diseases; * celiac disease; * cystic fibrosis or other forms of primary pancreatic insufficiency; * genetic and metabolic diseases; * food intolerances; * malignancy; * chronic pulmonary diseases; * malformations of the respiratory tract or of the gastrointestinal tract; * pre-, pro- or sinbiotic use in the previous 3 months; * antibiotics or gastric acidity inhibitors use in the previous 3 months.

Locations (1)

Department of Traslational Medical Science - University of Naples Federico II

Naples, Italy

Outcomes

Primary Outcomes

Evaluation of gut microbiome features in allergic children and in healthy controls.

Comparatively evaluation of gut microbiome features in allegic children and in healthy controls.

Time frame: at enrollment

Secondary Outcomes

Gut microbiome and allergy disease course

Evaluation of gut microbiome influence on allergy disease course

Time frame: at enrollment

Evaluation of gut microbiome features in children affected by different allergies (food and respiratory)

Comparatively evaluation of gut microbiome features in children with different allergies (food and respiratory)

Time frame: at enrollment

Evaluation of gut microbiome features in children affected by different type of food allergy

Time frame: at enrollment

Data from ClinicalTrials.gov

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