Food allergy derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for gut microbiota in oral tolerance development. An altered composition of gut microbiota results in an unbalanced local and systemic immune response to food allergens. There are qualitative and quantitative differences in gut microbiota composition in children with food allergy. Preliminary results of MATFA study demonstrated gut microbiota in allergic children.These findings support the pivotal role of the gut microbiota in the pathogenesis of allergic diseases and may open new strategies in the development of innovative preventive and therapeutic approaches.
Study Type
OBSERVATIONAL
Enrollment
120
food allergy
respiratory allergy
healthy controls
Department of Traslational Medical Science - University of Naples Federico II
Naples, Italy
Evaluation of gut microbiome features in allergic children and in healthy controls.
Comparatively evaluation of gut microbiome features in allegic children and in healthy controls.
Time frame: at enrollment
Gut microbiome and allergy disease course
Evaluation of gut microbiome influence on allergy disease course
Time frame: at enrollment
Evaluation of gut microbiome features in children affected by different allergies (food and respiratory)
Comparatively evaluation of gut microbiome features in children with different allergies (food and respiratory)
Time frame: at enrollment
Evaluation of gut microbiome features in children affected by different type of food allergy
Evaluation of gut microbiome features in children affected by different type of food allergy
Time frame: at enrollment
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