To determine if the use of Buscopan in patients undergoing IVF/ICSI treatment with high uterine contraction frequency prior to embryo transfer has a higher live birth rate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
675
cases will be randomized to Buscopan group or Normal Saline group, injection will be given 5 minutes prior to embryo transfer
Prince of Wales Hospital
Hong Kong, Hong Kong
live birth rate
live baby born
Time frame: after 24 weeks of gestation
implantation rate
positive pregnancy test
Time frame: 8-10 days after embryo transfer
clinical pregnancy rate
the presence of at least one gestational sac
Time frame: at 6 weeks gestation
multiple pregnancy rate
more than 1 live birth
Time frame: after 24 weeks of gestation
miscarriage rate
biochemical if there is no US evidence of pregnancy and clinical if there is US evidence of pregnancy
Time frame: before 24 weeks of gestation
ectopic pregnancy rate
IU sac out of uterine cavity
Time frame: at 6-7 weeks of gestation
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