A Phase I Study to Assess the Pharmacokinetics of Olorofim in Subjects With Hepatic Impairment

Inclusion Criteria: * Male or female subjects 18 to 70 years of age inclusive, at the time of signing the informed consent. * Body weight ≥50 kg and BMI within the range 18 to 35 kg/m2 (inclusive * Subjects with mild hepatic impairment will have grade A Child-Pugh score of 5 to 6 at screening and Day -1: * Subjects with moderate hepatic impairment: will have grade B Child-Pugh score of 7 to 9 at screening and Day -1 * Subjects with normal liver function must be in good health, as determined by a medical history, physical examination, vital signs, 12-lead ECG, and clinical laboratory evaluations * Subjects with normal liver function are matched by gender, age (±10 years) and BMI (± 20%) to at least one hepatically impaired subject. Exclusion Criteria: * Subjects who have an abnormality in the 12-lead ECG that, in the opinion of the Investigator, increases the risk of participating in the study * Subjects with any history of convulsion (other than childhood febrile convulsion before the age of 6 years). * Subjects who have any clinically significant allergic disease (excluding mild or seasonal allergies such as contact dermatitis or hay fever) as determined by the Investigator. * Subjects with a history of or any concomitant active malignancy. * Subjects with a history of drug or alcohol abuse. * Subjects with, or with a history of, any clinically significant neurological, renal, cardiovascular, psychiatric, respiratory, metabolic, endocrine, ocular (including minor trauma), hematological, or other major disorders as determined by the Investigator. * Subjects with signs or symptoms consistent with a COVID-19 infection at screening or Day -1 * Hepatically impaired subjects with liver transplantation, autoimmune liver disease, or drug-induced liver damage