The purpose of this research is to investigate whether patients who previously had endoprosthesis surgery experience memory, thinking, or heart problems. It will also help determine how often these problems occur.
At your first visit you will be asked to do the following: 1. Sign the consent document. 2. Patient Interview: An interview will be conducted by the study coordinator on the research team. They will ask your past surgical history, health history, medications, and your cognition. 3. Informant Interview: A close friend, spouse of relative of you will be interviewed about your day-day cognition. 4. Memory Interview: You will be evaluated on your memory and thinking skills three total times. One to determine baseline, and then repeated at one year and two years. You will answer questions that evaluate various thinking abilities such as concentration, memory, reasoning, and learning. 5. Blood Draw: You will have a blood draw three times (4.2-5 tablespoons) to determine your baseline, 1 year, and 2 year research results. 6: Echocardiogram: You will be asked to have three echocardiograms. One to determine baseline, and then repeated at one year and two years.
Study Type
OBSERVATIONAL
Enrollment
20
The patient and an informant will be asked to complete a questionnaire about his or hers current and past physical thinking abilities.
Cognition and memory interviews will take place with the patient.
Three blood draws will occur to assess patients immune response, metal levels, and cardiac health.
Mayo Clinic
Rochester, Minnesota, United States
Echo - Left Ventricular Ejection Fraction
The echocardiogram will measure changes in LV ejection fraction as a percent.
Time frame: Echo's will be taken at baseline, 1 year, and 2 years
Echo - Left Ventricular Mass
The echocardiogram will measure changes in LV Mass in grams.
Time frame: Echo's will be taken at baseline, 1 year, and 2 years
Echo - Heart Hypertrophy
The echocardiogram will measure changes in concentric or eccentric hypertrophy in centimeters.
Time frame: Echo's will be taken at baseline, 1 year, and 2 years
Cobalt Metal Levels
The change in cobalt blood ion levels will be measured in ng/mL.
Time frame: Cobalt level will be measured at baseline, 1 year, and 2 years
Chromium Metal Levels
The change in chromium blood ion levels will be measured in ng/mL.
Time frame: Chromium level will be measured at baseline, 1 year, and 2 years
Titanium Metal Levels
The change in titanium blood ion levels will be measured in ng/mL.
Time frame: Titanium level will be measured at baseline, 1 year, and 2 years
Psychometrist Testing - Intelligence Score
The change in participants' intelligence will be measured using the Wechsler Adult Intelligence Scale. The scale is based of scores of 50 to 150. The higher the score the better the outcome. The average outcome will be a score of 100.
Time frame: Testing will occur at baseline, 1 year, and 2 years.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Each echocardiogram takes about 3 hours and 30 minutes. This test uses sound waves to look at your heart. The person doing the test will press on your chest with a machine to obtain the pictures. The pressure may be uncomfortable. The echocardiogram will involve an image enhancement agent infusion to obtain better images.
Psychometrist Testing - Memory Score
The change in participants' memory will be measured using the Wechsler Adult Memory Scale. The scale is based of scores of 50 to 150. The higher the score the better the outcome. The average outcome will be a score of 100.
Time frame: Testing will occur at baseline, 1 year, and 2 years.