The study will be conducted as a randomized controlled trial with four parallel arms including four dairy products. We will investigate the health effects of including yogurt in the diet through a 16-weeks intervention period among 100 volunteering males with symptoms of the metabolic syndrome. The study has a total duration of 20 weeks as a wash out period of four weeks will be initiated prior to the intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
100
400 g/day of regular whole milk
400 g/day of yogurt with live bacteria
400 g/day of yogurt with inactivated bacteria
University of Copenhagen, Department of Nutrition, Exercise and Sports
Frederiksberg, DK, Denmark
Liver fat
Measurements of liver fat by Magnetic Resonance Imaging
Time frame: Change from Week 0 to week 16
Cardiometabolic risk
Measured by fasting cholesterol, HDL, LDL, Triglycerid and LDL fractions
Time frame: Change from Week 0 to week 16
Cardiometabolic risk
Measured by fasting ALAT
Time frame: Change from Week 0 to week 16
Cardiometabolic risk
Measured by fasting blood pressure (automatic device)
Time frame: Change from Week 0 to week 16
Gut microbiome
Measurments of microbiota (fecal spot samples)
Time frame: Change from week -4 to week 16
Glucose metabolism (fasting samples)
Measurements of fasting glucose, insulin, C-peptide, HbA1C
Time frame: Change from Week 0 to week 16
Glucose metabolism (5 hour oral glucose tolerance test)
Measurements of glucose, insulin and C-peptide during a 5 hour oral glucose tolerance test
Time frame: Week 16 (5 hour test)
Inflammation
Measurements of fasting CRP
Time frame: Change from Week 0 to week 16
Inflammation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
400 g/day of yogurt with acidified whole milk
Measurements of fasting IL-6
Time frame: Change from Week 0 to week 16
Inflammation
Measurements of fasting TNF-alfa
Time frame: Change from Week 0 to week 16
Body composition
Measurements of body weight (every week), height (stadiometer) (only at screening), waist and hip circumference (non-elastic tape), sagittal diameter (abdominal caliper) (only week 0 and 16) as wells as fat mass and fat free mass (whole body DXA scan) (only week 0 and 16).
Time frame: Change from week -4 to week 16
Fat disposition and pancreatic fat
Measurements of viceral, subcutaneous and pancreatic fat by Magnetic Resonance Imaging
Time frame: Change from Week 0 to week 16