The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy. Patients will be given medication based on their hemodynamics and asked to return for a repeat measurement.
When a patient presents to the Maternal Hypertension Center at Cabell Huntington Hospital, she will receive a non-invasive hemodynamic assessment via the NICaS system as per usual protocol. The NICaS system uses impedance cardiography which provides a reliable assessment of cardiovascular, respiratory, and fluid parameters. In typical practice, the vasodilator nifedipine is initiated for increased systemic vascular resistance and elevated cardiac output is treated with beta blockade (via either atenolol or labetalol). The medication to be given to each subject will be based on their hemodynamics. Specifically, nifedipine will be given for a mean arterial pressure \>100 and a beta blocker will be given for a cardiac output \>8 l/min. The patients will be asked to return in one week for repeat ICG measurement.
Study Type
OBSERVATIONAL
Enrollment
60
Maternal Hypertension Center at Cabell Huntington Hospital
Huntington, West Virginia, United States
RECRUITINGSystolic blood pressure
Measured in mmHg
Time frame: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Diastolic blood pressure
Measured in mmHg
Time frame: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Mean arterial pressure
Measured in mmHg
Time frame: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Heart rate
Measured in beats per minute
Time frame: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Cardiac output
Measured in liters per minute
Time frame: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Systemic vascular resistance
Measured by dynes · sec/cm\^-5
Time frame: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
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