Uterotonics for Severe Preeclampsia

Assiut University124 enrolled

Overview

The study compares the effect of Intravenous carbetocin versus combined use of intravenous oxytocin and rectal misoprostol for prevention of postpartum hemorrhage during delivery of women with severe preeclampsia

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

124

Conditions

Preeclampsia Severe

Interventions

CarbetocinDRUG

100 mcg of Carbetocin intravenous injection

OxytocinDRUG

10 IU oxytocin IV drip

MisoprostolDRUG

400 mcg rectal

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women which diagnosed with severe pre-eclampsia. * Singleton pregnancy. * Termination of pregnancy by Cesarean section after 28 weeks of gestation. Exclusion Criteria: * Suspected or proven placental abruption. * Known placenta Previa or acreata. * Multiple pregnancies. * Obesity (BMI \>35). * Anemia (\<9 g/dl). * Retained placental tissues. * Big baby (\> 4 kg). * Presence of coagulopathy. * Polyhydramnios. * Presence of Uterine fibroids. * Medical diseases as; cardiac, liver, renal or endocrine diseases. * General anesthesia.

Locations (1)

Assiut Faculty of Medicine

Asyut, Egypt

Outcomes

Primary Outcomes

The rate of postpartum hemorrhage more than 1000 ml

the amount of bleeding during and after CS

Time frame: 30 minutes

Data from ClinicalTrials.gov

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