Changes in Regional and Global Cardiac Contractility After Stimulation in Scar Zone with the NOGA System

University Hospital, Toulouse12 enrolled

Overview

Despite a decrease in voltage amplitude in post-infarction scar areas, greater voltage amplitudes are sometimes observed at the time of local extrasystoles mechanically induced by catheters. However, no study has investigated whether these electrical changes are associated with mechanical changes in local contractility. However, the voltage is closely correlated to the local contractile function as evidenced by the use of the NOGA system.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Myocardial Infarction

Interventions

NOGA TM probeDEVICE

Each subject will be his own witness since the linear local shortening (LLS) will be measured successively in all patients before, then after stimulation of the scar zone (comparison of LLS measured in sinus rhythm then during stimulation in the scar zone for each patient. Each subject being his own witness and the two recordings being made a few minutes apart, during the same procedure.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Patients who should undergo ventricular tachycardia (VT) ablation after a myocardial infarction according to current recommendations, namely: patients with ischemic heart disease (ICD) and with episodes of sustained ventricular tachycardia responsible for internal electric shocks by the implantable automatic defibrillator (ICD) (grade IB recommendation) OR * patients with an MIC and an ICD, presenting a first episode of sustained ventricular tachycardia (grade IIa, B recommendation) * Affiliated with a social protection scheme * Having signed an informed consent Exclusion Criteria: * Contraindication or non-indication for ventricular tachycardia ablation * Women who are pregnant or of childbearing age and without contraception, breastfeeding women * Patients without ischemic heart disease * Patients under guardianship, curatorship or legal protection.

Locations (1)

ROLLIN Anne

Toulouse, CHU de Toulouse, France

RECRUITING

Outcomes

Primary Outcomes

Evolution of LLS (linear local shortening) via the NOGATM system in percentage

Study the change in percentage of LLS during stimulation in a post-infarction scar zone identified by voltage mapping of the left ventricle with the NOGA system, compared to LLS in the same zone measured in atrial stimulation

Time frame: 1month

Secondary Outcomes

Evolution of global systolic function: left ventricular ejection fraction

Compare the left ventricular ejection fraction (in percentage) during stimulation in a scar area compared to a normal rhythm

Time frame: 1month

Evolution of the global systolic function: integral time velocity under aortic Translation results Evolution of the global systolic function: integral time velocity under aortic

Compare the integral time velocity under aortic (in centimeter) during stimulation in a scar area compared to a normal rhythm

Time frame: 1month

Evolution of the global systolic function: strain longitudinal global

Compare the strain longitudinal global(in percentage) during stimulation in a scar area compared to a normal rhythm

Time frame: 1month

Central Contacts

Anne ROLLIN, MD

CONTACT

5 61 32 24 29 rollin.a@chu-toulouse.fr

Philippe MAURY, MD

CONTACT

5 61 34 10 18 maury.p@chu-toulouse.fr

Data from ClinicalTrials.gov

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