This case-control study focuses on pain in HIV, which is common despite antiretroviral therapy and compromises quality of life, mental health and daily functioning. Specifically, it will investigate the relationships between psychosocial distress, inflammation and pain in HIV.
We plan to recruit 100 people and follow them for 6 months, taking repeated measures. Participants who report persistent pain at enrolment will be assessed at 0 (baseline), 2, 4, and 6 months. Participants who report no pain at enrolment will be assessed at 0 (baseline) and 6 months. All participants will also be invited to participate in weekly remote assessment of selected self-reported outcomes.
Study Type
OBSERVATIONAL
Enrollment
107
As above
Community Health Clinic [name withheld due to risk to participants]
[City Withheld Due to Risk to Participants], Western Cape, South Africa
Hopkins Symptom Checklist 25-item questionnaire
Psychosocial distress
Time frame: Baseline
Provoked inflammatory response
Multiplex assay
Time frame: Baseline
Brief Pain Inventory
Pain intensity
Time frame: Baseline
Secondary hyperalgesia (surface area)
Induced in a subgroup
Time frame: Baseline assessment only
Brief Pain Inventory
Pain locations
Time frame: Baseline
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