A Study of the Safety of and Immune Response to Varying Doses of a Vaccine Against COVID-19 in Healthy Adults

Inclusion Criteria: * Participants who, in the opinion of the investigator, can and will comply with the requirements of the protocol. * Written or thumb printed informed consent obtained from the participant prior to performance of any study specific procedure. * Healthy participants as established by medical history and clinical examination before entering into the study. * A male or female between, and including, 18 and 50 years of age at the time of first study intervention administration. * Body Mass Index\>18 Kg/m\^2 and \<30 Kg/m\^2. * Participants with following hematological/biochemical parameters: * White Blood Cells within the study designated laboratory normal range. Participants with FDA toxicity grade 1 differential cell counts and considered not clinically significant may be enrolled at the discretion of the investigator, and with the review and approval of the medical monitor. * Platelets = 125,000 - 500,000 cells/mm\^3. * Hemoglobin within normal range of the study designated laboratory. * Alanine aminotransferase within the study designated laboratory normal range. * Aspartate aminotransferase within the study designated laboratory normal range Total bilirubin within the study designated laboratory normal range. * Alkaline phosphatase within the study designated laboratory normal range. * Blood urea nitrogen within the study designated laboratory normal range. * Serum creatinine less than or equal to 1.1 times study designated laboratory's upper limit of normal. * Seronegative for hepatitis B surface antigen, hepatitis C virus antibodies, or human immunodeficiency virus antibodies. * Female participants of non-childbearing potential may be enrolled in the study. Non-childbearing potential is defined as pre-menarche, current bilateral tubal ligation or occlusion, hysterectomy, bilateral ovariectomy or post-menopause. * Female participants of childbearing potential may be enrolled in the study, if the participant: * has practiced adequate contraception for 1 month prior to study intervention administration, and, * has a negative pregnancy test on the day of study intervention administration, and, * has agreed to continue adequate contraception during the entire treatment period and for 2 months after completion of the study intervention administration series. Exclusion Criteria: Medical conditions * Individuals with signs and symptoms consistent with COVID-19, according to CDC guidelines and following clinical judgement. * Nasal and/or oral swab positive for SARS-CoV-2 by RT-PCR within the last 30 days, unless participant has had a subsequent negative swab and is asymptomatic. * Close contact (within 30 days prior to study intervention administration) with anyone known to have SARS-CoV-2 infection. * Individuals currently working in occupations with high risk of exposure to SARS-CoV-2 (e.g., healthcare workers, emergency response personnel). * Any confirmed or suspected immunosuppressive/immunodeficient condition based on medical history and physical examination. * Family history of congenital/hereditary immunodeficiency. * History of or current autoimmune disease. * History of any reaction/hypersensitivity likely to be exacerbated by any components of the study intervention. * History of hypersensitivity/severe allergic reaction to any previous licensed/unlicensed vaccine. * Lymphoproliferative disorder/malignancy within previous 5 years (excluding effectively treated non-melanotic skin cancer). * History of recurrent anemia within the last 6 months. * Hypersensitivity to latex. * Any acute/chronic, clinically significant disease The following conditions will be exclusionary: * Diabetes mellitus (type I or II), with exception of gestational diabetes. * Respiratory disease such as: * Chronic Pulmonary diseases, * Bronchopulmonary dysplasia, * Uncontrolled asthma/asthma necessitating treatment with chronic systemic/inhaled glucocorticoids. * Significant and/or uncontrolled psychiatric illness: * hospitalization for psychiatric illness, history of suicide attempts/confinement for danger to self/others within 5 years, * clinically significant depression. * Major neurological disease including: * seizure or adulthood epilepsy (note: history of febrile convulsion in childhood is not exclusionary), * myasthenia gravis, * history of repetitive migraine mal/status migrainosus. * Significant cardiovascular disease, including: * Uncontrolled arterial hypertension, * Congenital heart disease, * Previous myocardial infarction, * Valvular heart disease or history of rheumatic fever, * Previous bacterial endocarditis, * History of cardiac surgery, * Personal/ family history of cardiomyopathy/sudden adult death. * Asplenia, functional asplenia/any condition resulting in the absence/removal of the spleen. * Hereditary angioedema, acquired angioedema/ idiopathic forms of angioedema. * History of, or concurrent, autoimmune thyroid disease regardless of treatment and thyroid status as well as any uncontrolled thyroid disease. * Idiopathic urticaria within the past year. * Any other significant uncontrolled medical illness within 3 months prior to study intervention administration. * Acute illness and/or fever at the time of screening. Participants with acute illness and/ or fever at the time of screening may be re screened later. * Participants with a minor illness without fever may be enrolled. * Any other clinical condition that might pose additional risk to the participant due to participation in the study. Prior/Concomitant therapy * Use of any investigational or non-registered product other than the study intervention(s) during the period beginning 45 days before the first dose (Day -45 to Day 1), or their planned use during the study. * Planned administration/administration of a vaccine not foreseen by the study protocol in the period starting 30 days before the vaccination and ending 30 days after, with the exception of any licensed influenza vaccine which may be administered \>15 days before/after vaccination. * Planned administration/administration of an Emergency Use Authorization vaccine against SARS-CoV-2 in the period starting prior to the first dose of study intervention and ending 15 days after the second dose of study intervention * Administration of long-acting immune-modifying drugs at any time during the study * Administration of immunoglobulins and/or any blood products or plasma derivatives during the period starting 3 months before the administration of the first dose until study end. * Chronic administration of immunosuppressants/other immune-modifying drugs during the period starting 6 months prior to the first dose. For corticosteroids, this will mean prednisone equivalent \>10 mg/day. Topical steroids are allowed. Prior/Concurrent clinical study experience * Receipt of any other SARS-CoV-2 or other experimental coronavirus vaccine at any time prior to or during the study * Concurrently participating in another clinical study, at any time during the study period, in which the participant has been/will be exposed to an investigational/a non-investigational intervention Other exclusions * Pregnant/lactating female * Female planning to become pregnant/planning to discontinue contraceptive precautions * Alcohol and/or drug abuse. * Current/history of chronic tobacco/marijuana smoking/vaping. * Participants with extensive tattoos covering deltoid region on both the arms that would preclude the assessment of local reactogenicity.