Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP Due to Multilevel IDD

Inclusion Criteria: * Workers (it means subject has worked at least 2 months, even if not continuously, in the last 6 months) * Age between 18 and 65 years. * Signed informed consent. * Symptomatic chronic LBP due to moderate/severe IDD \[modified Pfirrmann score 3-5 (Pfirrmann et al., 2001), Griffith score 4-8 (Griffith et al., 2007)\] at max. 4 levels of the lumbar spine unresponsive to conservative treatment, physical and medical for at least 6 months. Physical treatment includes physiotherapy. Medical treatments includes AINS, paracetamol, opioids and myorelaxant. * Annulus fibrosus intact, demonstrated by MRI. * Pain baseline \> 40 mm on VAS (0- 100). * NSAID washout of at least 2 days before screening. * Painkillers washout of at least 24 hours before screening. * For females of childbearing potential, a negative pregnancy test must be documented at Screening. * Men and women should use effective contraception during treatment and for at least 12 months after BM-MSC discontinuation. The complete list of contraceptive methods is described in the patient information sheet and in the paragraph 6.5. As a precautionary measure, breast-feeding should be discontinued during treatment with BM-MSC and should not be restarted after discontinuation of BM-MSC. Exclusion Criteria: * Non-workers (it means that the person has worked less than 2 months, although not continuously, in the last 6 months) * Congenital or acquired diseases leading to spine deformations that may upset cell application (scoliosis, isthmus lesion, sacralization and hemisacralization, degenerative spondilolisthesis). * Spinal segmental instability assessed by dynamic X-Ray. * Symptomatic facet joints syndrome on MRI (facet joints hyperintensity and hypertrophy evaluated at coronal T2 weighted MRI). * Prior to the screening visit, has received: * Oral corticosteroid therapy within the previous 3 months, OR * Intramuscular, intravenous or epidural corticosteroid therapy within the previous 3 months * Presence of a 5th level with symptomatic IDD (modified Pfirrmann score 3-5, Griffith score 4-8) in the lumbar spine. * Spinal canal stenosis (Schizas score \> B). * History of spinal infection. * Lumbar disc herniation and sciatica. * Endplate abnormality such as Schmorl's Nodes. * Previous discal puncture or previous spine surgery. * IDD with Modic III changes on MRI images. * Patients not eligible to the intravertebral disc surgery. * Patients who have the risk to undergo a surgery in the next 6 months. * Patients with local infusion device/devices for corticosteroids. * Obesity with body mass index (BMI in Kg/size in m2) greater than 35 (obesity grade II). * Participation in another clinical trial or treatment with another investigational product within 30 days prior to inclusion in the study. * Abnormal blood tests: hepatic (alanine aminotransferase \[ALT\] and/or aspartate aminotransferase \[AST\] \>1.5 × upper limit of normal \[ULN\]), renal, pancreatic or biliary disease, blood coagulation disorders, anemia or platelet count of \<100 × 109/L. * Pregnant or lactating women, or premenopausal women not using an acceptable form of birth control, are ineligible for inclusion. Contraception will be maintained during treatment and until the end of relevant systemic exposure. Additional pregnancy testing will be performed at the end of relevant systemic exposure. The patients will be required to use contraception from initial treatment administration until 24 months after the last dose of study drug. * In each case of delayed menstrual period (over 1 month between menstruations), confirmation of absence of pregnancy is strongly recommended. The complete list of contraceptive methods is described in the patient information sheet. * Positive serology for following infection: Syphilis, HIV, Hepatitis B, or C. * Contraindication to MRI assessed by the investigator. * Intolerance or allergy to local anaesthesia. * Any history of Cancer or immunodeficiency disease. * Previous transplantation.