At a tertiary care university hospital a specialized interdisciplinary team of paediatric anaesthesiologists and paediatric intensivists was established for providing analgosedation for diagnostic and therapeutic procedures. The aim of the present study was to analyse the incidence and risk factors of adverse events during procedural sedation performed by the Children's Analgosedation Team (CAST).
At a tertiary care university hospital a dedicated Children's Analgosedation Team (CAST) performs all procedural sedations in children outside the operating room. Often patient age, comorbidities and procedures involving the airway are considered risk factors for adverse events, but previous studies investigating adverse events did not involve implementation of a specialised sedation team. Medical records of all children receiving procedural sedation by the CAST were reviewed for the incidence of adverse events. A bivariate analysis as well as an analysis of variance using type II Wald chi-square tests were conducted for identifying potential risk factors for adverse Events.
Study Type
OBSERVATIONAL
Enrollment
784
Incidence of adverse events
Respiratory, hemodynamic, and other adverse events
Time frame: From the beginning of sedation (administration of 1. sedation drug) until the end of sedation (patient regained consciousness), assessed up to 6 hours
Incidence of serious adverse events
Aspiration, vomiting/regurgitation, desaturation \< 90% for \> 30sec, hypotension \< 50% of baseline, laryngospasm, thorax rigidity, unplanned admission to Paediatric Intensive Care Unit (PICU), cardiac arrest, and death
Time frame: From the beginning of sedation (administration of 1. sedation drug) until the end of sedation (patient regained consciousness), assessed up to 6 hours
Age
Patient age in month
Time frame: At the beginning of sedation (administration of 1. sedation drug)
Sex
Male or female
Time frame: At the beginning of sedation (administration of 1. sedation drug)
American Society of Anesthesiology (ASA) status
ASA physical status I / II / III / IV
Time frame: At the beginning of sedation (administration of 1. sedation drug)
Date of sedation
Date as YEAR/MONTH/DAY
Time frame: At the beginning of sedation (administration of 1. sedation drug)
Category of the primary diagnosis
Diagnosis that prompted the need for the procedure, categorized according to the subspecialty (hematology/oncology, nephrology, hepatology, gastroenterology, metabolic medicine, neurology, pulmonology, cardiology)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: At the beginning of sedation (administration of 1. sedation drug)
Type and dose of sedative
Propofol or Midazolam in mg kg-1
Time frame: From the beginning of sedation (administration of 1. sedation drug) until the end of sedation (patient regained consciousness), assessed up to 6 hours
Type and dose of analgesic
Esketamine in mg kg-1 or remifentanil in µg kg-1 min-1
Time frame: From the beginning of sedation (administration of 1. sedation drug) until the end of sedation (patient regained consciousness), assessed up to 6 hours
Upper respiratory tract infection (URI)
Signs of runny nose and/or cough
Time frame: At the beginning of sedation (administration of 1. sedation drug)