The current proposal aims to test the feasibility of immune function analysis for Tai Chi Easy (TCE) intervention in multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT) with concurrent exploration of health related quality of life (HRQOL).
The current proposal aims to test the feasibility of immune function analysis for TCE intervention in MM patients undergoing ASCT with concurrent exploration of HRQOL. The data obtained from this trial will provide supporting data for a future randomized clinical trial evaluating the impact of TCE on immune function (incidence of ASCT related infectious complications, natural killer cell phenotype and activity, and myeloma remission rate (clonal plasma cell % at day 100, minimal residual disease (MRD)), with the evaluation of efficacy on improving HRQOL during ASCT. Successful completion of this CROC project will provide necessary data to support future grant applications, in particular the feasibility of immunoassay evaluation of MM patients undergoing ASCT.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
12
Patients will receive two 30-minute small group training sessions (Via Zoom) within 7 days of their scheduled transplant. After the training has been completed the participant will be provided with written (via manual) and electronic (DVD, MP3 file download) materials to continue with self-direct practice throughout the duration of the study.
University of Arizona
Tucson, Arizona, United States
Mayo Clinic
Jacksonville, Florida, United States
Determine natural killer cell phenotype
Determine natural killer (NK) phenotype through peripheral blood analysis
Time frame: Baseline
Determine natural killer cell phenotype
Determine natural killer (NK) phenotype through peripheral blood analysis
Time frame: Day 14
Determine natural killer cell phenotype
Determine natural killer (NK) phenotype through peripheral blood analysis
Time frame: Day 30
Determine natural killer cell phenotype
Determine natural killer (NK) phenotype through peripheral blood analysis
Time frame: Day 100
Determine NK cell activity
Determine NK cell activity through peripheral blood analysis
Time frame: At baseline
Determine NK cell activity
Determine NK cell activity through peripheral blood analysis
Time frame: Day 14
Determine NK cell activity
Determine NK cell activity through peripheral blood analysis
Time frame: Day 30
Determine NK cell activity
Determine NK cell activity through peripheral blood analysis
Time frame: Day 100
Determine immune function
Determine immune function through peripheral blood analysis of immune factors
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Time frame: At baseline
Determine immune function
Determine immune function through peripheral blood analysis of immune factors
Time frame: Day 14
Determine immune function
Determine immune function through peripheral blood analysis of immune factors
Time frame: Day 30
Determine immune function
Determine immune function through peripheral blood analysis of immune factors
Time frame: Day 100