To Evaluate the Efficacy and Safety of ADVAGRAF® After Treatment With a Tacrolimus in New Liver Transplant Recipients

Inclusion Criteria: * When the Subjects agree informed consent form, Subject should be More than 20 years of age * Those who are transplanated liver at a minimum of 10 weeks or Maximum of 14 weeks of baseline * Average of tacrorimus trough level is 3-10 ng/mL from transplanted date to before baseline. * Female subjects of child bearing potential must have a negative urine or serum pregnancy test prior to enrolment and at the end of study and must agree to practice effective birth control during the study.(The oral contraceptive pill is not allowed to take a female subject) ⑤Subjects are stable clinically in the opinion of the investigator. ⑥Subjects capable of understanding the purpose and risks of the study, having been fully informed and has given written informed consent to participate in the study Exclusion Criteria: * Subjects having previously received an organ transplant excluding liver transplant. Or Subjects receiving an auxiliary graft or in whom a bio-artificial liver(cell system) has been used. * Acute rejection from transplanted date to before baseline * Subjects diagnosed new malignant tumor after liver transplantation, with the exception of basalioma or squamous cell carcinoma of the skin that has been treated successfully. * Subjects allergic to tacrolimus or investigational product. * Subjects are unstable clinically state in the opinion of the investigator. * Subjects with any form of substance abuse, psychiatric disorder or condition which, in the opinion of the investigator, may complicate communication with the investigator. ⑦Subjects participating or having participated in another clinical trial and/or those taking or having taken an investigational / non-registered drug in the past 28 days. ⑧Subjects taking forbidden concomitant medications or within 28 days prior to enroll. * Subjects who are pregnant or breast-feeding mother. ⑩Subjects known to be HIV positive. ⑪Subjects unlikely to comply with the visits scheduled in the protocol. ⑫Subjects with renal dysfunction on the investigator's point of view or serum creatinine \> 1.6mg/dL or GFR(MDRD)\<30mL/min in the baseline. ⑬Hepatic dysfunction: rising more than triple the normal range of SGPT/ALT and/or SGOT/AST and/or bilirubin, hepatic cirrhosis