Quantitative MRI of Bone Marrow Fat Fraction in Patients With Trepanobiopsy

N/AUnknownNCT04761965

Federal Research Institute of Pediatric Hematology, Oncology and Immunology150 enrolled

Overview

The study is aimed to find correlation between the assessment of cellularity according to trepanobiopsy data and the results of measuring MRI parameters.

The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow. MRI may become a new non-invasive method for assessing the cellularity of the bone marrow in children with oncohematological diseases.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

150

Conditions

Aplastic Anemia Aplastic Anemia Idiopathic

Interventions

Bone marrow cellularity by mDixon-quantDIAGNOSTIC_TEST

if trepanobiopsy was performed during the diagnosis, then comparison with MRI Bone marrow cellularity by mDixon-quant

Eligibility

Sex: ALLMin age: 6 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: presence of indications for performing trepanobiopsy: 1. aplastic anemia 2. chronic myeloproliferative disease 3. reactive changes in hematopoiesis Exclusion Criteria: 1. Refusal to sign an informed consent to participate in a clinical trial 2. Presence of contraindications for MRI examination 3. Extremely serious condition of the patient at the time of inclusion in the study.

Locations (1)

Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology

Moscow, Samory-Mashela,1, Russia

RECRUITING

Outcomes

Primary Outcomes

correlation between Bone marrow cellularity by mDixon-quant and trepanobiopsy.

Determination of bone marrow cellularity before starting therapy for the underlying disease. Cellularity according to trepanobiopsy data is the ratio of stromal and hematopoietic cells to fat cells in the bone marrow. Cellularity according to MRI - the ratio of water and fat in the bone marrow using the mDixom Quant.