Evaluate the Efficacy and Safety of the ADVAGRAF®

Inclusion Criteria: 1. Aged between 19 and 80 years old 2. Those who were transplantated liver at a minimum of 12 month of screening and after 12 month Treatment with a Tacrolimus stably.(Brain dead transplantation or biological transplant no values) 3. tacrolimus blood everage level is 3-10 ng/ml for at least 6 months prior to screening. 4. Female subjects of child bearing potential must have a negative urine or serum pregnancy test prior to enrollment and at the end of study and must agree to practice effective birth control during the study. 5. Subjects are stable clinically in the opinion of the investigator. 6. Subjects capable of understanding the purpose and risks of the study, having been fully informed and has given written informed consent to participate in the study Exclusion Criteria: 1. Subjects having previously received an organ transplant excluding liver transplant. Or Subjects receiving an auxiliary graft or in whom a bio-artificial liver(cell system) has been used. 2. Acute rejection confirmed by histologic response or the patient had chronic rejection 3. Subjects diagnosed new malignant tumor before the pre-screening within five years , with the exception of basalioma or squamous cell carcinoma or carcinoma in situ of the skin that has been treated successfully. 4. Subjects allergic to tacrolimus or investigational product. 5. Subjects are unstable clinically state in the opinion of the investigator. 6. Subjects with any form of substance abuse, psychiatric disorder or condition which, in the opinion of the investigator, may complicate communication with the investigator. 7. Subjects participating or having participated in another clinical trial and/or those taking or having taken an investigational / non-registered drug in the past 28 days. 8. Subjects taking forbidden concomitant medications or within 28 days prior to enroll. 9. Subjects who are pregnant or breast-feeding mother. 10. Subjects unlikely to comply with the visits scheduled in the protocol. 11. Subjects with renal dysfunction on the investigator's point of view or serum creatinine \> 1.6mg/dL or GFR(MDRD)\<30mL/min in the baseline. 12. Hepatic dysfunction: rising more than double the normal range of SGPT/ALT and/or SGOT/AST and/or bilirubin, hepatic cirrhosis