This two-arm, double blind, randomized clinical trial will compare the effect of an avocado extract, compared to placebo, on cardiometabolic outcomes in adults with obesity.
Sixty eligible participants will be stratified by sex and randomly assigned to placebo or avocado extract supplementation group for 12 weeks. Metabolic testing will be performed at baseline, and at the end of the intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
60
Participants will consume 10 grams of freeze dried avocado daily for 12 weeks.
Participants will consume 10 grams of corn meal daily for 12 weeks.
The University of Adelaide
Adelaide, South Australia, Australia
Glycemic response
Change in glucose area under the curve (AUC) in response to 75 g oral glucose tolerance test
Time frame: 12 weeks
Fasting glucose
Change in fasting glucose
Time frame: 12 weeks
Fasting insulin
Change in fasting insulin
Time frame: 12 weeks
Postprandial insulin
Change in insulin AUC in response to 75g oral glucose tolerance test
Time frame: 12 weeks
Homeostatic model assessment of insulin resistance (HOMA-IR)
Change in HOMA-IR
Time frame: 12 weeks
Body weight
Change in body weight
Time frame: 12 weeks
Waist circumference
Change in waist circumference
Time frame: 12 weeks
Body composition
Change in body composition assessed by dual-energy X-ray absorptiometry (DEXA)
Time frame: 12 weeks
Blood pressure
Change in systolic and diastolic blood pressure
Time frame: 12 weeks
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Blood lipids
Change in total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides
Time frame: 12 weeks
C-reactive protein
Change in blood C-reactive protein
Time frame: 12 weeks
Oxidative stress
Change in blood isoprostane
Time frame: 12 weeks
Autophagy
Changes in blood mRNA levels of autophagy markers
Time frame: 12 weeks