Study to Evaluate Safety and Activity of TRL1068 in Prosthetic Joint Infections

Inclusion Criteria: * Diagnosis of PJI of the knee or hip * Identified pathogen(s) must be susceptible to antibiotic regimen * Planned/scheduled for primary two-stage exchange arthroplasty * BMI \< 40 kg/m² * Willing and able to provide written informed consent * Willing to perform and comply with all study procedures including attending clinic visits as scheduled. * Men and women of child bearing potential (WOCBP) must be willing to practice a highly effective method of contraception Exclusion Criteria: * Evidence of active infection other than bacterial PJI of the knee or hip * Inability to receive or intolerant to pathogen-appropriate systemic or oral antibiotic therapy * Chronic obstructive pulmonary disease (COPD) * Child-Pugh score \> 6 * Congestive heart failure * Immunocompromised individuals, including those receiving immunosuppressive doses of corticosteroids * Active malignancy, or history of malignancy or chemotherapy within the past 2 years * Active or history of autoimmune disease * Uncontrolled diabetes, defined as hemoglobin A1c \> 7.4% * Clinically significant abnormality on electrocardiogram (ECG) that would preclude subject from undergoing two-stage exchange arthroplasty * Clinically significant serum chemistry or hematology abnormalities * Any acute illness within 14 days of Day 1 that could confound the evaluation of safety evaluation * Known or suspected intolerance or hypersensitivity to any biologic medication * Received a therapeutic antibody or biologic within the 6 months prior to Screening * Positive serum test for pregnancy, pregnant, or nursing women * Positive reverse transcription polymerase chain reaction (RT -PCR) or alternative (antigen) test for acute respiratory syndrome coronavirus 2 * History of drug or alcohol abuse that, in the opinion of the Investigator, would interfere with the subject's ability to comply with the study requirements * Any other comorbidity or condition that, in the opinion of the Investigator would make the subject unsuitable for the study or unable to comply with the study requirements