An organ intended for transplantation is normally stored on ice (cold storage, CS) after explantation from the donor. During this storage process, damage to the endothelial glycocalyx occurs. It is known from numerous studies that the integrity of the endothelial glycocalyx is necessary for organ function. Normothermic machine perfusion is an alternative storage method for explanted livers, where the graft is perfused with warm blood. This study aims to clarify the influence of normothermic machine perfusion on endothelial glycocalyx damage of the graft.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
30
Blood samples will be collected from the patient at 5 different time points. Three perfusate samples will be collected during normothermic machine perfusion (4,9ml each).
Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine
Innsbruck, Tyrol, Austria
Syndecan 1 level during normothermic machine perfusion
Syndecan 1 level at the end of normothermic perfusion compared to the beginning of perfusion
Time frame: 24 hours
Heparansulfate level during normothermic machine perfusion
Heparansulfate level at the end of normothermic perfusion compared to the beginning of perfusion
Time frame: 24 hours
Syndecan 1 after transplantation
Change of Syndecan 1 level after transplantation
Time frame: 72 hours
Heparansulfate level after transplantation
Change of Syndecan 1 level after transplantation
Time frame: 72 hours
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