The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis patients.
45 sites with vertical intrabony alveolar defects will be selected. These defect sites will be allocated randomly into 3 groups as Group I, Group II and Group III. * Group I will be treated with open flap debridement and filled with A-PRF * Group II will be treated with open flap debridement and filled with Bioactive glass (Perioglas®) * Group III will be treated with open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
48
After phase 1 therapy, surgical procedure would be carried out in the selected patients under aseptic conditions. Full thickness mucoperiosteal Kirkland flap would be raised on both buccal and lingual sides using periosteal elevator. Pocket lining epithelium would be removed and a thorough debridement and root planing would be done in the intrabony defect by using Gracey curettes and universal curettes. After placement of A-PRF in bony defect site the mucoperiosteal flaps would be sutured for complete soft tissue closure.
After phase 1 therapy, surgical procedure would be carried out in the selected patients under aseptic conditions. Full thickness mucoperiosteal Kirkland flap would be raised on both buccal and lingual sides using periosteal elevator. Pocket lining epithelium would be removed and a thorough debridement and root planing would be done in the intrabony defect by using Gracey curettes and universal curettes. After placement of perioglas in bony defect site the mucoperiosteal flaps would be sutured for complete soft tissue closure.
Department of Periodontology, M.M. College of Dental Sciences and Research.
Ambāla, Haryana, India
probing depth
change in probing pocket depth
Time frame: baseline, 3 months, 6 months
relative attachment level
change in attachment level
Time frame: baseline, 3 months, 6 months
radiographic linear bone change
radiographic linear bone change through radiographic grid
Time frame: change from baseline to 6 months
Plaque index site specific
Plaque index -Silness and Loe
Time frame: baseline, 3 months, 6 months
Gingival index site specific
Gingival index- Loe and Silness
Time frame: baseline, 3 months, 6 months
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After phase 1 therapy, surgical procedure would be carried out in the selected patients under aseptic conditions. Full thickness mucoperiosteal Kirkland flap would be raised on both buccal and lingual sides using periosteal elevator. Pocket lining epithelium would be removed and a thorough debridement and root planing would be done in the intrabony defect by using Gracey curettes and universal curettes. After placement of perioglas with A-PRF in bony defect site the mucoperiosteal flaps would be sutured for complete soft tissue closure.