NCT04767685 - The Bern Perioperative Biobank | Crick

Overview

The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression. To better understand the perioperative impact the investigators aim to determine perioperative levels of molecular markers over time in the available samples and clinical data of the Bern perioperative Biobank (BPBB) cohort to finally increase quality of perioperative care of patients by permitting preventive measures to be taken early in patients at risk.

Study Type

OBSERVATIONAL

Enrollment

547

Conditions

Anesthesia Surgical Procedure, Operative

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years and older * Written informed consent * Non-emergency surgery Exclusion Criteria * Transient incapacity to consent or insufficient time (\< 6h) to consider study participation * No informed consent * Cognitive impairment/Patients unable to consent * Patients who retrospectively expressed their wish to be excluded

Locations (1)

Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

Bern, Switzerland

Outcomes

Primary Outcomes

Assessing the change of the metabolic profile in the perioperative setting

Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.

Time frame: Before induction of anesthesia as baseline

Assessing the change of the metabolic profile in the perioperative setting

Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.

Time frame: Ca. 2-5hours later upon finishing the surgery

Assessing the change of the metabolic profile in the perioperative setting

Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.

Time frame: On postoperative day 1 during the morning round between 07:30-9:00am